PMID- 25770818
OWN - NLM
STAT- MEDLINE
DCOM- 20160927
LR  - 20220318
IS  - 1872-6240 (Electronic)
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 1628
IP  - Pt A
DP  - 2015 Dec 2
TI  - What goes up, can come down: Novel brain stimulation paradigms may attenuate 
      craving and craving-related neural circuitry in substance dependent individuals.
PG  - 199-209
LID - S0006-8993(15)00188-2 [pii]
LID - 10.1016/j.brainres.2015.02.053 [doi]
AB  - Vulnerability to drug related cues is one of the leading causes for continued use 
      and relapse among substance dependent individuals. Using drugs in the face of 
      cues may be associated with dysfunction in at least two frontal-striatal neural 
      circuits: (1) elevated activity in medial and ventral areas that govern limbic 
      arousal (including the medial prefrontal cortex (MPFC) and ventral striatum) or 
      (2) depressed activity in dorsal and lateral areas that govern cognitive control 
      (including the dorsolateral prefrontal cortex (DLPFC) and dorsal striatum). 
      Transcranial magnetic stimulation (TMS) is emerging as a promising new tool for 
      the attenuation of craving among multiple substance dependent populations. To 
      date however, nearly all repetitive TMS studies in addiction have focused on 
      amplifying activity in frontal-striatal circuits that govern cognitive control. 
      This manuscript reviews recent work using TMS as a tool to decrease craving for 
      multiple substances and provides a theoretical model for how clinical researchers 
      might approach target and frequency selection for TMS of addiction. To buttress 
      this model, preliminary data from a single-blind, sham-controlled, crossover 
      study of 11 cocaine-dependent individuals is also presented. These results 
      suggest that attenuating MPFC activity through theta burst stimulation decreases 
      activity in the striatum and anterior insula. It is also more likely to attenuate 
      craving than sham TMS. Hence, while many TMS studies are focused on applying 
      LTP-like stimulation to the DLPFC, the MPFC might be a new, efficacious, and 
      treatable target for craving in cocaine dependent individuals.
CI  - Copyright (c) 2015. Published by Elsevier B.V.
FAU - Hanlon, Colleen A
AU  - Hanlon CA
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, USA; Department of Neurosciences, Medical University of South Carolina, 
      USA; Center for Biomedical Imaging, Medical University of South Carolina, USA. 
      Electronic address: hanlon@musc.edu.
FAU - Dowdle, Logan T
AU  - Dowdle LT
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, USA; Department of Neurosciences, Medical University of South Carolina, 
      USA.
FAU - Austelle, Christopher W
AU  - Austelle CW
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, USA.
FAU - DeVries, William
AU  - DeVries W
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, USA.
FAU - Mithoefer, Oliver
AU  - Mithoefer O
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, USA.
FAU - Badran, Bashar W
AU  - Badran BW
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, USA; Department of Neurosciences, Medical University of South Carolina, 
      USA.
FAU - George, Mark S
AU  - George MS
AD  - Department of Psychiatry and Behavioral Sciences, Medical University of South 
      Carolina, USA; Department of Neurosciences, Medical University of South Carolina, 
      USA; Center for Biomedical Imaging, Medical University of South Carolina, USA; 
      Ralph H Johnson Veterans Affairs Medical Center, USA.
LA  - eng
GR  - K01DA027756/DA/NIDA NIH HHS/United States
GR  - P50 DA015369/DA/NIDA NIH HHS/United States
GR  - UL1 TR000062/TR/NCATS NIH HHS/United States
GR  - R01DA036617/DA/NIDA NIH HHS/United States
GR  - P50 AA010761/AA/NIAAA NIH HHS/United States
GR  - K01 DA027756/DA/NIDA NIH HHS/United States
GR  - R25 DA033680/DA/NIDA NIH HHS/United States
GR  - R01 DA036617/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Review
DEP - 20150311
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
SB  - IM
MH  - Brain/*physiopathology
MH  - Craving/*physiology
MH  - Humans
MH  - Neural Pathways/physiopathology
MH  - Substance-Related Disorders/*physiopathology/psychology/*therapy
MH  - Transcranial Magnetic Stimulation/*methods
PMC - PMC4899830
MID - NIHMS785545
OTO - NOTNLM
OT  - BA 10
OT  - Brain stimulation
OT  - Caudate
OT  - Functional MRI
OT  - Orbitofrontal cortex
EDAT- 2015/03/17 06:00
MHDA- 2016/09/28 06:00
PMCR- 2016/06/09
CRDT- 2015/03/16 06:00
PHST- 2014/08/10 00:00 [received]
PHST- 2015/01/29 00:00 [revised]
PHST- 2015/02/10 00:00 [accepted]
PHST- 2015/03/16 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2016/09/28 06:00 [medline]
PHST- 2016/06/09 00:00 [pmc-release]
AID - S0006-8993(15)00188-2 [pii]
AID - 10.1016/j.brainres.2015.02.053 [doi]
PST - ppublish
SO  - Brain Res. 2015 Dec 2;1628(Pt A):199-209. doi: 10.1016/j.brainres.2015.02.053. 
      Epub 2015 Mar 11.