PMID- 25771541
OWN - NLM
STAT- MEDLINE
DCOM- 20150901
LR  - 20190923
IS  - 1000-8713 (Print)
IS  - 1000-8713 (Linking)
VI  - 32
IP  - 11
DP  - 2014 Nov
TI  - [Enantioseparation and determination of atenolol enantiomers in tables on a 
      beta-cyclodextrin-based chiral stationary phase by high performance liquid 
      chromatography].
PG  - 1219-24
AB  - A novel dinitrophenyl ether beta-cyclodextrin-bonded chiral stationary phase (NESP) 
      for HPLC was prepared with ordered mesoporous SBA-15 as matrix. The fast 
      enantioseparation of atenolol enantiomers on the new stationary phase was 
      achieved through the optimization of mobile phase composition, column temperature 
      and other factors in polar organic solvent mode. The optimized composition of 
      mobile phase was acetonitrile/methanol/glacial acetic acid/triethylamine 
      (90:10:2.5:3.0, v/v/v/v) at the flow rate of 0.5 mL/min. The column tem- perature 
      was set at 20  degrees C. The detection wavelength was 275 nm. The resolution of atenolol 
      enantiomers was 1.73 with a rather short analysis time, about 20 min, under the 
      above conditions. The atenolol was extracted with methanol from the tablets and 
      analyzed by direct injection for HPLC. A new quantitative method of atenolol 
      enantiomers in tablets was established after the condition optimization. The good 
      linear relationships for two atenolol enantiomers were observed in the range of 
      2.5-100 mg/L with r of 0. 999 2 and 0. 998 9, respectively. The recoveries of 
      atenolol enantiomers in tablet samples were 94.60%-97.24%. The relative standard 
      deviations (RSDs) of this method were not greater than 0.92% for intra-day and 
      1.86% for inter-day, respectively. The detection limits (S/N = 3) of 
      concentrations were less than 0.2 mg/L for both enantiomers. The established 
      method is simple and of high selectivity, high recovery and low cost for 
      enantiomer analysis by using homemade cyclodextrin-based chiral column. It has a 
      good application prospect for the fast quality control and the pharmacokinetics 
      study of chiral drugs.
FAU - Cheng, Biaoping
AU  - Cheng B
FAU - Li, Laisheng
AU  - Li L
FAU - Zhou, Rendan
AU  - Zhou R
FAU - Nie, Guizhen
AU  - Nie G
FAU - Zhang, Hongfu
AU  - Zhang H
LA  - chi
PT  - Journal Article
PL  - China
TA  - Se Pu
JT  - Se pu = Chinese journal of chromatography
JID - 9424804
RN  - 0 (Tablets)
RN  - 0 (beta-Cyclodextrins)
RN  - 50VV3VW0TI (Atenolol)
SB  - IM
MH  - Atenolol/*analysis
MH  - Chromatography, High Pressure Liquid
MH  - Stereoisomerism
MH  - Tablets
MH  - beta-Cyclodextrins
EDAT- 2015/03/17 06:00
MHDA- 2015/09/02 06:00
CRDT- 2015/03/17 06:00
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2015/09/02 06:00 [medline]
AID - 10.3724/sp.j.1123.2014.07018 [doi]
PST - ppublish
SO  - Se Pu. 2014 Nov;32(11):1219-24. doi: 10.3724/sp.j.1123.2014.07018.