PMID- 25771930
OWN - NLM
STAT- MEDLINE
DCOM- 20160516
LR  - 20181113
IS  - 1476-5497 (Electronic)
IS  - 0307-0565 (Linking)
VI  - 39
IP  - 7
DP  - 2015 Jul
TI  - Fasting substrate oxidation at rest assessed by indirect calorimetry: is prior 
      dietary macronutrient level and composition a confounder?
PG  - 1114-7
LID - 10.1038/ijo.2015.29 [doi]
AB  - Indirect calorimetry, the measurement of O(2) consumption and CO(2) production, 
      constitutes an invaluable tool as the most common method for analyzing whole-body 
      energy expenditure, and also provides an index of the nature of macronutrient 
      substrate oxidation--namely, carbohydrate (CHO) versus fat oxidation. The latter 
      constitutes a key etiological factor in obesity as this condition can only 
      develop when total fat oxidation is chronically lower than total exogenous fat 
      intake. The standardization of indirect calorimetry measurements is essential for 
      accurately tracking the relative proportion of energy expenditure derived from 
      CHO and fat oxidation. Here we analyze literature data to show that the average 
      fasting respiratory quotient typically shifts from approximately 0.80 to 0.90 
      (indicating a doubling of resting CHO oxidation) in response to a switch in 
      dietary CHO intake (as % energy) from 30 to 60%. This underscores the importance 
      of taking into account dietary macronutrient composition prior to indirect 
      calorimetry studies in the interpretation of data on substrate utilization and 
      oxidation.
FAU - Miles-Chan, J L
AU  - Miles-Chan JL
AD  - Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, 
      Switzerland.
FAU - Dulloo, A G
AU  - Dulloo AG
AD  - Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, 
      Switzerland.
FAU - Schutz, Y
AU  - Schutz Y
AD  - Division of Physiology, Department of Medicine, University of Fribourg, Fribourg, 
      Switzerland.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150316
PL  - England
TA  - Int J Obes (Lond)
JT  - International journal of obesity (2005)
JID - 101256108
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
SB  - IM
MH  - *Calorimetry, Indirect
MH  - Dietary Carbohydrates/*metabolism
MH  - Dietary Fats/*metabolism
MH  - Energy Metabolism/*physiology
MH  - Fasting/metabolism
MH  - Humans
MH  - Obesity/*metabolism
MH  - Rest/physiology
EDAT- 2015/03/17 06:00
MHDA- 2016/05/18 06:00
CRDT- 2015/03/17 06:00
PHST- 2014/09/16 00:00 [received]
PHST- 2015/02/23 00:00 [revised]
PHST- 2015/03/03 00:00 [accepted]
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2016/05/18 06:00 [medline]
AID - ijo201529 [pii]
AID - 10.1038/ijo.2015.29 [doi]
PST - ppublish
SO  - Int J Obes (Lond). 2015 Jul;39(7):1114-7. doi: 10.1038/ijo.2015.29. Epub 2015 Mar 
      16.