PMID- 25771936
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20150519
IS  - 1814-1412 (Electronic)
IS  - 1562-2975 (Linking)
VI  - 16
IP  - 4
DP  - 2015 Jun
TI  - Functional outcome in major psychiatric disorders and associated clinical and 
      psychosocial variables: A potential cross-diagnostic phenotype for further 
      genetic investigations?
PG  - 237-48
LID - 10.3109/15622975.2014.995221 [doi]
AB  - OBJECTIVES: Functional outcome has recently become of interest for 
      cross-diagnostic subphenotype approaches in psychiatric genetics. Therefore, it 
      is crucial to know about clinical, demographic and psychosocial variables that 
      correlate with long-term functioning. Unfortunately, there is a lack of studies 
      that directly compare the importance of correlates for functional outcome between 
      different disorders. METHODS: Applying regression models to samples of patients 
      with schizophrenia (SZ, n = 238), bipolar disorder (BD, n = 533) and major 
      depressive disorder (MDD, n = 398), we compared the magnitude of association of 
      potential correlates with functional outcome, measured by the Global Assessment 
      of Functioning (GAF) score. RESULTS: Shared correlates for worse functional 
      outcome were poor premorbid functioning, insidious illness onset and poor 
      premorbid work or social adjustment in all three disorders, and negative 
      symptomatology in SZ and BD. Disorder-specific correlates for SZ were longer 
      duration of illness, lower functioning during episodes and being life-time 
      single, for BD substance abuse and suicidality, and for MDD premorbid 
      unemployment and having a premorbid personality disorder. CONCLUSIONS: We found 
      different patterns of correlates for long-term functioning in SZ, BD and MDD. 
      Knowledge of these patterns may improve the quality of genetic investigations 
      focussing on functional outcome.
FAU - Gade, Katrin
AU  - Gade K
AD  - Department of Psychiatry and Psychotherapy, University Medical Center, 
      Georg-August University , Gottingen , Germany.
FAU - Malzahn, Dorthe
AU  - Malzahn D
FAU - Anderson-Schmidt, Heike
AU  - Anderson-Schmidt H
FAU - Strohmaier, Jana
AU  - Strohmaier J
FAU - Meier, Sandra
AU  - Meier S
FAU - Frank, Josef
AU  - Frank J
FAU - Falkai, Peter G
AU  - Falkai PG
FAU - Rietschel, Marcella
AU  - Rietschel M
FAU - Schulze, Thomas G
AU  - Schulze TG
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150314
PL  - England
TA  - World J Biol Psychiatry
JT  - The world journal of biological psychiatry : the official journal of the World 
      Federation of Societies of Biological Psychiatry
JID - 101120023
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bipolar Disorder/genetics/*physiopathology
MH  - Depressive Disorder, Major/genetics/*physiopathology
MH  - Female
MH  - Humans
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Models, Psychological
MH  - Personality Disorders
MH  - Phenotype
MH  - Psychiatric Status Rating Scales
MH  - Schizophrenia/genetics/*physiopathology
MH  - Suicide
MH  - Unemployment
MH  - Young Adult
OTO - NOTNLM
OT  - bipolar disorder
OT  - global functioning
OT  - major depression
OT  - schizophrenia
OT  - subphenotype
EDAT- 2015/03/17 06:00
MHDA- 2016/02/05 06:00
CRDT- 2015/03/17 06:00
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - 10.3109/15622975.2014.995221 [doi]
PST - ppublish
SO  - World J Biol Psychiatry. 2015 Jun;16(4):237-48. doi: 
      10.3109/15622975.2014.995221. Epub 2015 Mar 14.