PMID- 25772368
OWN - NLM
STAT- MEDLINE
DCOM- 20160809
LR  - 20151021
IS  - 1099-1263 (Electronic)
IS  - 0260-437X (Linking)
VI  - 35
IP  - 12
DP  - 2015 Dec
TI  - Time profiles and toxicokinetic parameters of key biomarkers of exposure to 
      cypermethrin in orally exposed volunteers compared with previously available 
      kinetic data following permethrin exposure.
PG  - 1586-93
LID - 10.1002/jat.3124 [doi]
AB  - Biomonitoring of pyrethroid exposure is largely conducted but human 
      toxicokinetics has not been fully documented. This is essential for a proper 
      interpretation of biomonitoring data. Time profiles and toxicokinetic parameters 
      of key biomarkers of exposure to cypermethrin in orally exposed volunteers have 
      been documented and compared with previously available kinetic data following 
      permethrin dosing. Six volunteers ingested 0.1 mg kg(-1) bodyweight of 
      cypermethrin acutely. The same volunteers were exposed to permethrin earlier. 
      Blood samples were taken over 72 h after treatment and complete timed urine voids 
      were collected over 84 h postdosing. Cis- and 
      trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane-1-carboxylic acids (trans- 
      and cis-DCCA) and 3-phenoxybenzoic acid (3-PBA) metabolites, common to both 
      cypermethrin and permethrin, were quantified. Blood and urinary time courses of 
      all three metabolites were similar following cypermethrin and permethrin 
      exposure. Plasma levels of metabolites reached peak values on average  approximately  5-7 h 
      post-dosing; the elimination phase showed mean apparent half-lives (t(1/2) ) for 
      trans-DCCA, cis-DCCA and 3-PBA of 5.1, 6.9 and 9.2 h, respectively, following 
      cypermethrin treatment as compared to 7.1, 6.2 and 6.5 h after permethrin dosing. 
      Corresponding mean values obtained from urinary rate time courses were peak 
      values at  approximately  9 h post-dosing and apparent elimination t(1/2) of 6.3, 6.4 and 6.4 h for 
      trans-DCCA, cis-DCCA and 3-PBA, respectively, following cypermethrin treatment as 
      compared to 5.4, 4.5 and 5.7 h after permethrin dosing. These data confirm that 
      the kinetics of cypermethrin is similar to that of permethrin in humans and that 
      their common biomarkers of exposure may be used for an overall assessment of 
      exposure.
CI  - Copyright (c) 2015 John Wiley & Sons, Ltd.
FAU - Ratelle, Mylene
AU  - Ratelle M
AD  - Department of Environmental and Occupational Health, Chair in Toxicological Risk 
      Assessment and Management, and University of Montreal Public Health Research 
      Institute (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, PO 
      Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7.
FAU - Cote, Jonathan
AU  - Cote J
AD  - Department of Environmental and Occupational Health, Chair in Toxicological Risk 
      Assessment and Management, and University of Montreal Public Health Research 
      Institute (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, PO 
      Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7.
FAU - Bouchard, Michele
AU  - Bouchard M
AD  - Department of Environmental and Occupational Health, Chair in Toxicological Risk 
      Assessment and Management, and University of Montreal Public Health Research 
      Institute (IRSPUM), University of Montreal, Roger-Gaudry Building, U424, PO 
      Box 6128, Main Station, Montreal, Quebec, Canada, H3C 3J7.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150313
PL  - England
TA  - J Appl Toxicol
JT  - Journal of applied toxicology : JAT
JID - 8109495
RN  - 0 (Biomarkers)
RN  - 0 (Insecticides)
RN  - 0 (Pyrethrins)
RN  - 1TR49121NP (cypermethrin)
RN  - 509F88P9SZ (Permethrin)
SB  - IM
MH  - Administration, Oral
MH  - Adult
MH  - Biomarkers/blood/urine
MH  - Environmental Exposure/*analysis
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - *Insecticides/blood/urine
MH  - Male
MH  - *Permethrin/blood/urine
MH  - *Pyrethrins/blood/urine
MH  - Toxicokinetics
MH  - Young Adult
OTO - NOTNLM
OT  - 3-PBA
OT  - DCCA
OT  - Exposure biomarkers
OT  - cypermethrin
OT  - oral exposure
OT  - permethrin
OT  - pyrethroids
EDAT- 2015/03/17 06:00
MHDA- 2016/08/10 06:00
CRDT- 2015/03/17 06:00
PHST- 2014/10/09 00:00 [received]
PHST- 2014/11/27 00:00 [revised]
PHST- 2014/12/22 00:00 [accepted]
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2016/08/10 06:00 [medline]
AID - 10.1002/jat.3124 [doi]
PST - ppublish
SO  - J Appl Toxicol. 2015 Dec;35(12):1586-93. doi: 10.1002/jat.3124. Epub 2015 Mar 13.