PMID- 25773729
OWN - NLM
STAT- MEDLINE
DCOM- 20160627
LR  - 20150918
IS  - 1541-0420 (Electronic)
IS  - 0006-341X (Linking)
VI  - 71
IP  - 3
DP  - 2015 Sep
TI  - Penalized regression for interval-censored times of disease progression: 
      Selection of HLA markers in psoriatic arthritis.
PG  - 782-91
LID - 10.1111/biom.12302 [doi]
AB  - Times of disease progression are interval-censored when progression status is 
      only known at a series of assessment times. This situation arises routinely in 
      clinical trials and cohort studies when events of interest are only detectable 
      upon imaging, based on blood tests, or upon careful clinical examination. We 
      consider the problem of selecting important prognostic biomarkers from a large 
      set of candidates when disease progression status is only known at irregularly 
      spaced and individual-specific assessment times. Penalized regression techniques 
      (e.g., LASSO, adaptive LASSO, and SCAD) are adapted to handle interval-censored 
      time of disease progression. An expectation-maximization algorithm is described 
      which is empirically shown to perform well. Application to the motivating study 
      of the development of arthritis mutilans in patients with psoriatic arthritis is 
      given and several important human leukocyte antigen (HLA) variables are 
      identified for further investigation.
CI  - (c) 2015, The International Biometric Society.
FAU - Wu, Ying
AU  - Wu Y
AD  - Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, 
      Ontario, Canada N2L 3G1.
FAU - Cook, Richard J
AU  - Cook RJ
AD  - Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, 
      Ontario, Canada N2L 3G1.
LA  - eng
GR  - FRN 13887/Canadian Institutes of Health Research/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150313
PL  - England
TA  - Biometrics
JT  - Biometrics
JID - 0370625
RN  - 0 (Biomarkers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Algorithms
MH  - Arthritis, Psoriatic/blood/*diagnosis/*epidemiology
MH  - Biomarkers/blood
MH  - *Disease Progression
MH  - HLA Antigens/*blood
MH  - Humans
MH  - Prevalence
MH  - *Regression Analysis
MH  - Reproducibility of Results
MH  - Risk Assessment/methods
MH  - Sensitivity and Specificity
MH  - *Severity of Illness Index
MH  - Time Factors
OTO - NOTNLM
OT  - EM algorithm
OT  - Interval-censoring
OT  - LASSO
OT  - Penalized regression
OT  - SCAD
OT  - Variable selection
EDAT- 2015/03/17 06:00
MHDA- 2016/06/28 06:00
CRDT- 2015/03/17 06:00
PHST- 2013/09/01 00:00 [received]
PHST- 2014/12/01 00:00 [revised]
PHST- 2015/02/01 00:00 [accepted]
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2016/06/28 06:00 [medline]
AID - 10.1111/biom.12302 [doi]
PST - ppublish
SO  - Biometrics. 2015 Sep;71(3):782-91. doi: 10.1111/biom.12302. Epub 2015 Mar 13.