PMID- 25774362
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150316
LR  - 20201001
IS  - 2287-6375 (Print)
IS  - 2287-7029 (Electronic)
IS  - 2287-6375 (Linking)
VI  - 22
IP  - 1
DP  - 2015 Feb
TI  - Risk of hip fractures in men with alpha-blockers: a nationwide study base on 
      claim registry.
PG  - 29-32
LID - 10.11005/jbm.2015.22.1.29 [doi]
AB  - BACKGROUND: Alpha-blocker can result in falling and fractures because of adverse 
      effect such as orthostatic hypotension due to vasodilatory effect. We 
      investigated the association between the alpha-blocker and the risk of 
      osteoporotic hip fractures using a nationwide claim database. METHODS: We 
      identified 1,051,651 men 65 years of age or older who had prescription records of 
      alpha-blocker from nationwide medical claim database, from 2007 to 2012. 
      Alpha-blockers were classified as non-specific general (NSG), non-specific 
      slow-release (NSSR), uro-specific general (USG), and uro-specific slow release 
      (USSR). RESULTS: Total of 6,553 hip fractures were observed. The incidences of 
      hip fracture within 1 year were higher than those of the reference periods in all 
      type of alpha-blocker. Hazard ratio peaked at early period of alpha-blocker, and 
      decreased with time, regardless of type of alpha-blocker. CONCLUSIONS: Use of 
      alpha-blocker is associated with increased risk of hip fracture, especially in 
      early use.
FAU - Seo, Gi-Hyeon
AU  - Seo GH
AD  - Health Insurance Review and Assessment Service, Seoul, Korea.
FAU - Lee, Young-Kyun
AU  - Lee YK
AD  - Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 
      Seongnam, Korea.
FAU - Ha, Yong-Chan
AU  - Ha YC
AD  - Department of Orthopaedic Surgery, Chung-Ang University College of Medicine, 
      Seoul, Korea.
LA  - eng
PT  - Journal Article
DEP - 20150228
PL  - Korea (South)
TA  - J Bone Metab
JT  - Journal of bone metabolism
JID - 101599927
PMC - PMC4357634
OTO - NOTNLM
OT  - Alpha-blocker
OT  - Hip fracture
OT  - Registries
COIS- No potential conflict of interest relevant to this article was reported.
EDAT- 2015/03/17 06:00
MHDA- 2015/03/17 06:01
PMCR- 2015/02/01
CRDT- 2015/03/17 06:00
PHST- 2015/02/10 00:00 [received]
PHST- 2015/02/22 00:00 [revised]
PHST- 2014/02/23 00:00 [accepted]
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2015/03/17 06:01 [medline]
PHST- 2015/02/01 00:00 [pmc-release]
AID - 10.11005/jbm.2015.22.1.29 [doi]
PST - ppublish
SO  - J Bone Metab. 2015 Feb;22(1):29-32. doi: 10.11005/jbm.2015.22.1.29. Epub 2015 Feb 
      28.