PMID- 25774437
OWN - NLM
STAT- MEDLINE
DCOM- 20160706
LR  - 20191210
IS  - 1744-4136 (Electronic)
IS  - 0929-7049 (Linking)
VI  - 22
IP  - 4
DP  - 2016
TI  - Developmental neuropsychological assessment of 4- to 5-year-old children born 
      following Preimplantation Genetic Diagnosis (PGD): A pilot study.
PG  - 458-71
LID - 10.1080/09297049.2015.1014900 [doi]
AB  - The purpose of this pilot study was to evaluate developmental neuropsychological 
      profiles of 4- to 5-year-old children born after Preimplantation Genetic 
      Diagnosis (PGD). Twenty-seven participants received a neurological examination 
      and a battery of neuropsychological assessments including Wechsler Preschool & 
      Primary Scale of Intelligence - Third Edition (WPPSI-III; cognitive development), 
      Preschool Language Scale, Fourth Edition (PLS-4; language development), Wide 
      Range Assessment of Visual Motor Abilities (visual motor abilities), Childhood 
      Autism Rating Scales II (a screening test for autistic spectrum disorders), and 
      the Miles ABC Test (ocular dominance). Parental questionnaires included the 
      Behavior Rating Inventory of Executive Function Preschool Version (BRIEF-P; 
      executive function), Child Behavior Checklist (CBCL) and the Carey Temperament 
      Scales Behavioral Style Questionnaire (socioemotional development and 
      temperament), and the Vineland Adaptive Behavior Scales, Interview Edition, 
      Second Edition (general adaptive behavior). Subjects' tests results were compared 
      to each test's norms. Children born after PGD demonstrated scores within the 
      normal or above-normal ranges for all developmental outcomes (mean +/- SD): 
      WPPSI-III-VIQ 107.4 +/- 14.4 (p = .013), PLS-4-Total 113.2 +/- 12.4, p < .001), 
      CBCL-Total 41.1 +/- 8.6 (p < .001), BRIEF-P-Global Executive Composite 44.8 +/- 9.5 
      (p = .009). Twelve (44%) of the PGD children had a significant difference between 
      their VIQ and PIQ scores (compared to 27% in the general population). One subject 
      was found to show possible signs of autistic spectrum disorder, although a family 
      history of autism was noted. In conclusion, in this pilot study, children 
      assessed at age 4-5 years and conceived after PGD displayed developmental 
      neuropsychological outcomes within normal limits as compared to their chronologic 
      peers. A larger study is needed to evaluate and follow the neuropsychological 
      development of children born after PGD.
FAU - Sacks, Gilat Chaya
AU  - Sacks GC
AD  - a ZOHAR PGD Unit , Medical Genetics Institute, Shaare Zedek Medical Center , 
      Jerusalem , Israel.
AD  - b Neuropsychology Unit, Shaare Zedek Medical Center , Jerusalem , Israel.
AD  - e Faculty of Medicine , Hebrew University , Jerusalem , Israel.
FAU - Altarescu, Gheona
AU  - Altarescu G
AD  - a ZOHAR PGD Unit , Medical Genetics Institute, Shaare Zedek Medical Center , 
      Jerusalem , Israel.
AD  - e Faculty of Medicine , Hebrew University , Jerusalem , Israel.
FAU - Guedalia, Judith
AU  - Guedalia J
AD  - b Neuropsychology Unit, Shaare Zedek Medical Center , Jerusalem , Israel.
FAU - Varshaver, Irit
AU  - Varshaver I
AD  - c Reproductive Endocrinology and Genetics Unit, IVF Unit, Shaare Zedek Medical 
      Center , Jerusalem , Israel.
FAU - Gilboa, Tal
AU  - Gilboa T
AD  - d Pediatric Neurology Unit , Shaare Zedek Medical Center , Jerusalem , Israel.
FAU - Levy-Lahad, Ephrat
AU  - Levy-Lahad E
AD  - a ZOHAR PGD Unit , Medical Genetics Institute, Shaare Zedek Medical Center , 
      Jerusalem , Israel.
AD  - e Faculty of Medicine , Hebrew University , Jerusalem , Israel.
FAU - Eldar-Geva, Talia
AU  - Eldar-Geva T
AD  - c Reproductive Endocrinology and Genetics Unit, IVF Unit, Shaare Zedek Medical 
      Center , Jerusalem , Israel.
AD  - e Faculty of Medicine , Hebrew University , Jerusalem , Israel.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
DEP - 20150316
PL  - England
TA  - Child Neuropsychol
JT  - Child neuropsychology : a journal on normal and abnormal development in childhood 
      and adolescence
JID - 9512515
SB  - IM
MH  - Adaptation, Psychological
MH  - Child
MH  - *Child Development
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Intelligence
MH  - *Language Development
MH  - Male
MH  - Neurologic Examination/*methods/statistics & numerical data
MH  - Neuropsychological Tests/*statistics & numerical data
MH  - Parents/psychology
MH  - Pilot Projects
MH  - Pregnancy
MH  - *Preimplantation Diagnosis
MH  - Social Behavior
MH  - Surveys and Questionnaires
MH  - Wechsler Scales
OTO - NOTNLM
OT  - Children follow-up
OT  - Developmental assessment
OT  - Embryo biopsy
OT  - Mixed eye-hand dominance
OT  - Neuropsychological outcome
OT  - Preimplantation Genetic Diagnosis
EDAT- 2015/03/17 06:00
MHDA- 2016/07/07 06:00
CRDT- 2015/03/17 06:00
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2016/07/07 06:00 [medline]
AID - 10.1080/09297049.2015.1014900 [doi]
PST - ppublish
SO  - Child Neuropsychol. 2016;22(4):458-71. doi: 10.1080/09297049.2015.1014900. Epub 
      2015 Mar 16.