PMID- 25774463
OWN - NLM
STAT- MEDLINE
DCOM- 20151228
LR  - 20220410
IS  - 1528-1159 (Electronic)
IS  - 0362-2436 (Linking)
VI  - 40
IP  - 6
DP  - 2015 Mar 15
TI  - The minimum clinically important difference in SRS-22R total score, appearance, 
      activity and pain domains after surgical treatment of adult spinal deformity.
PG  - 377-81
LID - 10.1097/BRS.0000000000000761 [doi]
AB  - STUDY DESIGN: Longitudinal cohort. OBJECTIVE: To establish minimum clinically 
      important difference (MCID) threshold values for Scoliosis Research Society-22R 
      (SRS-22R) domains in patients with adult spinal deformity undergoing surgical 
      correction. SUMMARY OF BACKGROUND DATA: The SRS-22R has been shown to be 
      reliable, valid and responsive to change in patients with adult spinal deformity 
      undergoing surgery. The MCID quantifies a threshold of improvement that is 
      clinically relevant to the patient. METHODS: Patients in a prospective database 
      who completed the SRS-22R preoperatively and the SRS-30 1 year postoperatively 
      were identified. Answers to the last 8 questions of the SRS-30 were used as 
      anchors to determine MCID for the pain, appearance and activity domains, 
      subscore, and total score using receiver-operating-characteristic curve analysis. 
      Calculations of MCID using distribution-based methods were also done. RESULTS: A 
      total of 1321 patients were included in the analysis; 83% were females and 10% 
      were smokers. Mean age was 53 years. Mean body mass index was 26.3 kg/m. Mean 
      preoperative SRS-22R appearance score was 2.50 improving to 3.62 at 1 year 
      postoperatively (P < 0.001). Mean preoperative SRS-22R activity score was 2.96 
      and it improved to 3.33 at 1 year postoperatively (P < 0.001). Mean preoperative 
      SRS-22R pain score was 2.73 improving to 3.60 at 1 year postoperatively (P < 
      0.001). Mean preoperative total score was 2.93 and it improved to 3.65 at 1 year 
      postoperatively (P < 0.001). There was a statistically significant difference in 
      domain scores among the responses to the anchors (P < 0.001). The different 
      calculation methods yielded MCID values of 0.19 to 1.23 for appearance, 0.23 to 
      0.60 for activity, 0.24 to 0.57 for pain, 0.16 to 0.43 for subscore, and 0.17 to 
      0.71 for total score. CONCLUSION: When combined with previous reports, the 
      results of this study in a population with adult spinal deformity undergoing 
      surgical treatment show MCID for SRS-22 scores can be estimated as 0.4. This 
      corresponds to a change of 1 interval in 2 of the 5 questions for a single 
      domain. LEVEL OF EVIDENCE: 2.
FAU - Crawford, Charles H 3rd
AU  - Crawford CH 3rd
AD  - *Norton Leatherman Spine Center, Louisville, KY daggerDepartment of Orthopaedic 
      Surgery, University of Louisville School of Medicine, ACB Louisville, KY 
      double daggerDepartment of Orthopaedic Surgery, Washington University School of Medicine, St. 
      Louis, MO; and  section signDepartment of Orthopaedic Surgery, University of California San 
      Francisco, San Francisco, CA.
FAU - Glassman, Steven D
AU  - Glassman SD
FAU - Bridwell, Keith H
AU  - Bridwell KH
FAU - Berven, Sigurd H
AU  - Berven SH
FAU - Carreon, Leah Y
AU  - Carreon LY
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Spine (Phila Pa 1976)
JT  - Spine
JID - 7610646
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Reference Values
MH  - Severity of Illness Index
MH  - Spinal Curvatures/diagnosis/*physiopathology/*surgery
EDAT- 2015/03/17 06:00
MHDA- 2015/12/29 06:00
CRDT- 2015/03/17 06:00
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2015/12/29 06:00 [medline]
AID - 00007632-201503150-00009 [pii]
AID - 10.1097/BRS.0000000000000761 [doi]
PST - ppublish
SO  - Spine (Phila Pa 1976). 2015 Mar 15;40(6):377-81. doi: 
      10.1097/BRS.0000000000000761.