PMID- 25774705
OWN - NLM
STAT- MEDLINE
DCOM- 20150921
LR  - 20181113
IS  - 1824-7288 (Electronic)
IS  - 1720-8424 (Linking)
VI  - 41
DP  - 2015 Feb 15
TI  - Policaptil Gel Retard significantly reduces body mass index and hyperinsulinism 
      and may decrease the risk of type 2 diabetes mellitus (T2DM) in obese children 
      and adolescents with family history of obesity and T2DM.
PG  - 10
LID - 10.1186/s13052-015-0109-7 [doi]
LID - 10
AB  - BACKGROUND: Treatments for childhood obesity are critically needed because of the 
      risk of developing co-morbidities, although the interventions are frequently 
      time-consuming, frustrating, difficult, and expensive. PATIENTS AND METHODS: We 
      conducted a longitudinal, randomised, clinical study, based on a per protocol 
      analysis, on 133 obese children and adolescents (n = 69 males and 64 females; 
      median age, 11.3 years) with family history of obesity and type 2 diabetes 
      mellitus (T2DM). The patients were divided into three arms: Arm A (n = 53 
      patients), Arm B (n = 45 patients), and Arm C (n = 35 patients) patients were 
      treated with a low-glycaemic-index (LGI) diet and Policaptil Gel Retard, only a 
      LGI diet, or only an energy-restricted diet (ERD), respectively. The homeostasis 
      model assessment of insulin resistance (HOMA-IR) and the Matsuda, insulinogenic 
      and disposition indexes were calculated at T0 and after 1 year (T1). RESULTS: At 
      T1, the BMI-SD scores were significantly reduced from 2.32 to 1.80 (p < 0.0001) 
      in Arm A and from 2.23 to 1.99 (p < 0.05) in Arm B. Acanthosis nigricans was 
      significantly reduced in Arm A (13.2% to 5.6%; p < 0.05), and 
      glycosylated-haemoglobin levels were significantly reduced in Arms A (p < 0.005). 
      The percentage of glucose-metabolism abnormalities was reduced, although not 
      significantly. However, the HOMA-IR index was significantly reduced in Arms A 
      (p < 0.0001) and B (p < 0.05), with Arm A showing a significant reduction in the 
      insulinogenic index (p < 0.05). Finally, the disposition index was significantly 
      improved in Arms A (p < 0.0001) and B (p < 0.05). CONCLUSIONS: A LGI diet, 
      particularly associated with the use of Policaptil Gel Retard, may reduce weight 
      gain and ameliorate the metabolic syndrome and insulin-resistance parameters in 
      obese children and adolescents with family history of obesity and T2DM.
FAU - Stagi, Stefano
AU  - Stagi S
FAU - Lapi, Elisabetta
AU  - Lapi E
FAU - Seminara, Salvatore
AU  - Seminara S
FAU - Pelosi, Paola
AU  - Pelosi P
FAU - Del Greco, Paolo
AU  - Del Greco P
FAU - Capirchio, Laura
AU  - Capirchio L
FAU - Strano, Massimo
AU  - Strano M
FAU - Giglio, Sabrina
AU  - Giglio S
FAU - Chiarelli, Francesco
AU  - Chiarelli F
FAU - de Martino, Maurizio
AU  - de Martino M
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150215
PL  - England
TA  - Ital J Pediatr
JT  - Italian journal of pediatrics
JID - 101510759
RN  - 0 (Gels)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Polysaccharides)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Comorbidity
MH  - Diabetes Mellitus, Type 2/*epidemiology/genetics
MH  - Female
MH  - Gels
MH  - Glycemic Index
MH  - Humans
MH  - Hyperinsulinism/*prevention & control
MH  - Macromolecular Substances/*therapeutic use
MH  - Male
MH  - Obesity/genetics
MH  - Pediatric Obesity/*epidemiology
MH  - Polysaccharides/*therapeutic use
MH  - Risk Factors
MH  - Treatment Outcome
PMC - PMC4339082
EDAT- 2015/03/17 06:00
MHDA- 2015/09/22 06:00
PMCR- 2015/02/15
CRDT- 2015/03/17 06:00
PHST- 2014/08/31 00:00 [received]
PHST- 2015/01/07 00:00 [accepted]
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2015/09/22 06:00 [medline]
PHST- 2015/02/15 00:00 [pmc-release]
AID - s13052-015-0109-7 [pii]
AID - 109 [pii]
AID - 10.1186/s13052-015-0109-7 [doi]
PST - epublish
SO  - Ital J Pediatr. 2015 Feb 15;41:10. doi: 10.1186/s13052-015-0109-7.