PMID- 25774735
OWN - NLM
STAT- MEDLINE
DCOM- 20150709
LR  - 20150317
IS  - 1439-4413 (Electronic)
IS  - 0012-0472 (Linking)
VI  - 140
IP  - 6
DP  - 2015 Mar
TI  - [Tropheryma whipplei: pathogen of Whipple's disease and more].
PG  - 428-32
LID - 10.1055/s-0041-100846 [doi]
AB  - Within the last years the understanding of infection with Tropheryma whipplei was 
      significantly enhanced by improvement of molecular biology, microbiology and 
      immunology. The following entities of infection or carriage, respectively, with 
      T. whipplei must be differentiated: besides in the context of classical Whipple's 
      disease (CWD), the rare chronic infection with T. whipplei (estimated incidence: 
      1 : 1,000,000), T. whipplei can be detected more frequently in stool specimens of 
      children with acute gastroenteritis or asymptomatic carriers, or as a cause of 
      isolated endocarditis. However, infection with T. whipplei only rarely results in 
      CWD. T. whipplei was well characterized, raised in vitro and its genome 
      completely sequenced within the last two decades. Very interesting is the 
      resistance of the agent against glutaraldehyde.The histological detection within 
      duodenal biopsies with "Periodic Acid Schiff" (PAS) staining still is first 
      choice for the diagnosis of CWD. Today PCR or immunohistochemistry can identify 
      the agent more specifically. In cases of isolated organ manifestations of e. g. 
      joints or central nervous system the agent needs to be identified from specimen 
      from the affected sites. Successful treatment can be achieved in most of the 
      cases by antimicrobial therapy and first prospective treatment trials are 
      published. However, neuronal CWD still can be progressive lethal and an immune 
      reconstitution inflammatory syndrome (IRIS) might complicate the course of 
      treatment and in worst case end fatal. Thus, because of the complexity of the 
      disease a specialised reference centre should be consulted for diagnosis and 
      treatment of CWD.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Schneider, Thomas
AU  - Schneider T
AD  - Medizinische Klinik I, Charite, Campus Benjamin Franklin, Berlin.
FAU - Moos, Verena
AU  - Moos V
AD  - Medizinische Klinik I, Charite, Campus Benjamin Franklin, Berlin.
LA  - ger
PT  - English Abstract
PT  - Journal Article
PT  - Review
TT  - Tropheryma whipplei: Erreger verschiedener Infektionen und Pathogen des Morbus 
      Whipple.
DEP - 20150316
PL  - Germany
TA  - Dtsch Med Wochenschr
JT  - Deutsche medizinische Wochenschrift (1946)
JID - 0006723
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Anti-Inflammatory Agents)
SB  - IM
MH  - Anti-Bacterial Agents/*therapeutic use
MH  - Anti-Inflammatory Agents/*therapeutic use
MH  - Humans
MH  - *Tropheryma
MH  - Whipple Disease/*diagnosis/*drug therapy/microbiology
EDAT- 2015/03/17 06:00
MHDA- 2015/07/15 06:00
CRDT- 2015/03/17 06:00
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2015/07/15 06:00 [medline]
AID - 10.1055/s-0041-100846 [doi]
PST - ppublish
SO  - Dtsch Med Wochenschr. 2015 Mar;140(6):428-32. doi: 10.1055/s-0041-100846. Epub 
      2015 Mar 16.