PMID- 25775429
OWN - NLM
STAT- MEDLINE
DCOM- 20160329
LR  - 20181113
IS  - 1465-993X (Electronic)
IS  - 1465-9921 (Print)
IS  - 1465-9921 (Linking)
VI  - 16
IP  - 1
DP  - 2015 Feb 7
TI  - Imbalance of dendritic cell co-stimulation in COPD.
PG  - 19
LID - 10.1186/s12931-015-0174-x [doi]
LID - 19
AB  - BACKGROUND: Dendritic cells (DCs) control immunity and play a role in the 
      pathogenesis of chronic obstructive pulmonary disease (COPD). However, the 
      expression of function-associated surface molecules on circulating DCs in COPD is 
      unknown. METHODS: Four-colour flow cytometry was used to compare blood DC surface 
      molecules of 54 patients with COPD (median age: 59 years; median FEV1: 38% 
      predicted, median CAT score: 24) with two age-matched control groups with normal 
      lung function: 21 current smokers and 21 never-smokers. RESULTS: Concentrations 
      of plasmacytoid DCs (pDCs) and myeloid DCs (mDCs) and the mDC/pDC ratio did not 
      differ between the groups. The increased expression of BDCA-1, BDCA-3, CD86 and 
      CCR5 on mDCs in patients with COPD did not significantly differ from smokers with 
      normal lung function. In contrast, COPD was specifically characterised by a 
      decreased expression of the anti-inflammatory co-stimulatory molecule PD-L1 on 
      pDCs and an increased expression of the pro-inflammatory co-stimulatory molecule 
      OX40 ligand (OX40L) on mDCs. These changes were not confined to patients with 
      elevated systemic inflammation markers (leukocytes, c-reactive protein, 
      interleukin-6, fibrinogen). The ratio of OX40L to PD-L1 expression (OX40L/PD-L1 
      ratio), a quantitative measure of imbalanced DC co-stimulation, correlated with 
      the severity of pulmonary emphysema in patients with COPD. CONCLUSION: An 
      imbalance of DC co-stimulation might contribute to the pathogenesis of COPD.
FAU - Stoll, Paul
AU  - Stoll P
AD  - Abteilung fur Pneumologie und Internistische Intensivmedizin, Zentrum fur Innere 
      Medizin, Universitat Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany. 
      dr.paul.stoll@googlemail.com.
FAU - Ulrich, Martin
AU  - Ulrich M
AD  - Abteilung fur Pneumologie und Internistische Intensivmedizin, Zentrum fur Innere 
      Medizin, Universitat Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany. 
      martin.ulrich@hotmail.de.
FAU - Bratke, Kai
AU  - Bratke K
AD  - Abteilung fur Pneumologie und Internistische Intensivmedizin, Zentrum fur Innere 
      Medizin, Universitat Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany. 
      kai.bratke@web.de.
FAU - Garbe, Katharina
AU  - Garbe K
AD  - Abteilung fur Pneumologie und Internistische Intensivmedizin, Zentrum fur Innere 
      Medizin, Universitat Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany. 
      Katharina.Garbe@gmx.net.
FAU - Virchow, J Christian
AU  - Virchow JC
AD  - Abteilung fur Pneumologie und Internistische Intensivmedizin, Zentrum fur Innere 
      Medizin, Universitat Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany. 
      jc.h.virchow@sunrise.ch.
FAU - Lommatzsch, Marek
AU  - Lommatzsch M
AD  - Abteilung fur Pneumologie und Internistische Intensivmedizin, Zentrum fur Innere 
      Medizin, Universitat Rostock, Ernst-Heydemann-Str. 6, 18057, Rostock, Germany. 
      marek.lommatzsch@med.uni-rostock.de.
LA  - eng
PT  - Journal Article
DEP - 20150207
PL  - England
TA  - Respir Res
JT  - Respiratory research
JID - 101090633
RN  - 0 (Antigens, Surface)
RN  - 0 (Biomarkers)
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antigens, Surface/blood/*immunology
MH  - Biomarkers/blood
MH  - Case-Control Studies
MH  - Cytokines/blood/*immunology
MH  - Dendritic Cells/*immunology/metabolism/physiology
MH  - Female
MH  - Flow Cytometry
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Inflammation Mediators/blood/*immunology
MH  - Lung/*immunology/metabolism/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Disease, Chronic 
      Obstructive/blood/diagnosis/*immunology/physiopathology
MH  - Pulmonary Emphysema/blood/diagnosis/*immunology/physiopathology
MH  - Severity of Illness Index
MH  - Smoking/adverse effects
PMC - PMC4335663
EDAT- 2015/03/17 06:00
MHDA- 2016/03/30 06:00
PMCR- 2015/02/07
CRDT- 2015/03/17 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2015/01/19 00:00 [accepted]
PHST- 2015/03/17 06:00 [entrez]
PHST- 2015/03/17 06:00 [pubmed]
PHST- 2016/03/30 06:00 [medline]
PHST- 2015/02/07 00:00 [pmc-release]
AID - s12931-015-0174-x [pii]
AID - 174 [pii]
AID - 10.1186/s12931-015-0174-x [doi]
PST - epublish
SO  - Respir Res. 2015 Feb 7;16(1):19. doi: 10.1186/s12931-015-0174-x.