PMID- 25776943
OWN - NLM
STAT- MEDLINE
DCOM- 20151103
LR  - 20220410
IS  - 1930-739X (Electronic)
IS  - 1930-7381 (Linking)
VI  - 23
IP  - 4
DP  - 2015 Apr
TI  - Serum betatrophin concentrations are significantly increased in overweight but 
      not in obese or type 2 diabetic individuals.
PG  - 793-7
LID - 10.1002/oby.21038 [doi]
AB  - OBJECTIVE: In this study, circulating serum betatrophin levels were quantitated 
      and their relationships with insulin resistance (IR) and other metabolic 
      parameters in Chinese subjects with varying degrees of obesity and glucose 
      tolerance were examined. METHODS: Serum betatrophin levels were determined using 
      ELISA in 60 subjects with normal glucose tolerance (NGT: 17 lean, 23 overweight, 
      and 20 obese subjects) and 56 subjects with type 2 diabetes mellitus (T2DM: 14 
      lean, 23 overweight, and 19 obese subjects). The associations of serum 
      betatrophin levels with adiposity, glucose, lipid profile, and hepatic enzyme 
      parameters were studied. RESULTS: Serum betatrophin concentrations were 
      significantly higher in overweight subjects in both the NGT and T2DM groups; 
      however, no significant difference between lean and obese participants was 
      observed. No significant difference was found between males and females or 
      between NGT and T2DM subjects. Serum betatrophin concentrations correlated 
      positively with fasting insulin, homeostasis model assessment-estimated insulin 
      resistance (HOMA-IR), gamma-glutamyl transpeptidase (gamma-GT), and alanine 
      aminotransferase (ALT) in all subjects. Serum betatrophin concentrations showed 
      an independent association with gamma-GT and HOMA-IR. CONCLUSIONS: Serum betatrophin 
      levels were significantly increased in overweight individuals but not in 
      individuals with obesity or T2DM. Serum betatrophin concentrations were 
      significantly associated with IR, but not with lipid profiles, glucose 
      homeostasis, or diabetes.
CI  - (c) 2015 The Obesity Society.
FAU - Guo, Kaifeng
AU  - Guo K
AD  - Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, 
      Shanghai Clinical Center for Diabetes, Department of Endocrinology and 
      Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, 
      Shanghai, China.
FAU - Lu, Junxi
AU  - Lu J
FAU - Yu, Haoyong
AU  - Yu H
FAU - Zhao, Fangya
AU  - Zhao F
FAU - Pan, Pan
AU  - Pan P
FAU - Zhang, Lei
AU  - Zhang L
FAU - Chen, Haibing
AU  - Chen H
FAU - Bao, Yuqian
AU  - Bao Y
FAU - Jia, Weiping
AU  - Jia W
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150316
PL  - United States
TA  - Obesity (Silver Spring)
JT  - Obesity (Silver Spring, Md.)
JID - 101264860
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Angiopoietin-like Proteins)
RN  - 0 (Insulin)
RN  - 0 (Peptide Hormones)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Angiopoietin-Like Protein 8
MH  - Angiopoietin-like Proteins
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*metabolism
MH  - Female
MH  - Humans
MH  - Insulin/blood
MH  - Insulin Resistance/*physiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/metabolism
MH  - Obesity, Morbid/*metabolism
MH  - Peptide Hormones/*blood
MH  - Risk Factors
EDAT- 2015/03/18 06:00
MHDA- 2015/11/04 06:00
CRDT- 2015/03/18 06:00
PHST- 2014/09/18 00:00 [received]
PHST- 2014/12/23 00:00 [revised]
PHST- 2014/12/28 00:00 [accepted]
PHST- 2015/03/18 06:00 [entrez]
PHST- 2015/03/18 06:00 [pubmed]
PHST- 2015/11/04 06:00 [medline]
AID - 10.1002/oby.21038 [doi]
PST - ppublish
SO  - Obesity (Silver Spring). 2015 Apr;23(4):793-7. doi: 10.1002/oby.21038. Epub 2015 
      Mar 16.