PMID- 25778331
OWN - NLM
STAT- MEDLINE
DCOM- 20150430
LR  - 20221207
IS  - 1107-0625 (Print)
IS  - 1107-0625 (Linking)
VI  - 20
IP  - 1
DP  - 2015 Jan-Feb
TI  - Association between estrogen receptor 1 (ESR1) genetic variations and cancer 
      risk: a meta-analysis.
PG  - 296-308
AB  - PURPOSE: Emerging published reports on the association between estrogen receptor 
      1 (ESR1) genetic variation and cancer susceptibility are inconsistent. This 
      review and meta- analysis was performed to achieve a more precise evaluation of 
      this relationship. METHODS: A literature search of PubMed database was conducted 
      from the inception of this study through April 1st 2014. Crude odds ratios (ORs) 
      with 95% confidence intervals (95% CIs) were calculated to assess the 
      association. RESULTS: 87 studies were enrolled in this meta-analysis. The results 
      indicated that PvuII (T>C) polymorphism was associated with an increased risk of 
      hepatocellular carcinoma (HCC) and prostate cancer, in contrast with the 
      decreased risk of gallbladder cancer. No significant association was found in 
      Asian and Caucasian populations. Furthermore, XbaI (A>G) genetic variation was 
      only associated with an increased risk of prostate cancer, but was not related 
      with race. In addition, T594T (G>A) polymorphisms were significantly associated 
      with an increased risk of cancer, especially in Asian populations. CONCLUSIONS: 
      This meta-analysis indicated that PvuII (T>C) genetic variation may be risk 
      factor for HCC, prostate cancer and gallbladder cancer. Meanwhile, XbaI (A>G) 
      polymorphism may be potential prognostic factor for prostate cancer. Furthermore, 
      T594T (G>A) was closely related with cancer susceptibility, especially in Asian 
      populations.
FAU - Sun, Huiling
AU  - Sun H
AD  - Department of Life Sciences, Nanjing Normal University, Nanjing, China.
FAU - Deng, Qiwen
AU  - Deng Q
FAU - Pan, Yuqin
AU  - Pan Y
FAU - He, Bangshun
AU  - He B
FAU - Ying, Houqun
AU  - Ying H
FAU - Chen, Jie
AU  - Chen J
FAU - Liu, Xian
AU  - Liu X
FAU - Wang, Shukui
AU  - Wang S
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Cyprus
TA  - J BUON
JT  - Journal of B.U.ON. : official journal of the Balkan Union of Oncology
JID - 100883428
RN  - 0 (ESR1 protein, human)
RN  - 0 (Estrogen Receptor alpha)
SB  - IM
MH  - Asian People/genetics
MH  - Carcinoma, Hepatocellular/diagnosis/ethnology/*genetics
MH  - Chi-Square Distribution
MH  - Estrogen Receptor alpha/*genetics
MH  - Female
MH  - Gallbladder Neoplasms/diagnosis/ethnology/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Liver Neoplasms/diagnosis/ethnology/*genetics
MH  - Male
MH  - Odds Ratio
MH  - *Polymorphism, Genetic
MH  - Prostatic Neoplasms/diagnosis/ethnology/*genetics
MH  - Risk Assessment
MH  - Risk Factors
EDAT- 2015/03/18 06:00
MHDA- 2015/05/01 06:00
CRDT- 2015/03/18 06:00
PHST- 2015/03/18 06:00 [entrez]
PHST- 2015/03/18 06:00 [pubmed]
PHST- 2015/05/01 06:00 [medline]
PST - ppublish
SO  - J BUON. 2015 Jan-Feb;20(1):296-308.