PMID- 25779340
OWN - NLM
STAT- MEDLINE
DCOM- 20151218
LR  - 20181202
IS  - 1674-8018 (Electronic)
IS  - 1674-800X (Print)
IS  - 1674-800X (Linking)
VI  - 6
IP  - 4
DP  - 2015 Apr
TI  - Human BDCA2+CD123+CD56+ dendritic cells (DCs) related to blastic plasmacytoid 
      dendritic cell neoplasm represent a unique myeloid DC subset.
PG  - 297-306
LID - 10.1007/s13238-015-0140-x [doi]
AB  - Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid 
      DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive 
      secretion of type I interferon (IFN-I) in response to nucleic acids through Toll 
      like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC 
      population that express typical pDC markers including CD123 and BDCA2 but produce 
      much less IFN-I comparing with pDCs. In addition, CD56(+) DCs cluster together 
      with mDCs but not pDCs by genome-wide transcriptional profiling. Accordingly, 
      CD56(+) DCs functionally resemble mDCs by producing IL-12 upon TLR4 stimulation 
      and priming naive T cells without prior activation. These data suggest that the 
      CD56(+) DCs represent a novel mDC subset mixed with some pDC features. A 
      CD4(+)CD56(+) hematological malignancy was classified as blastic plasmacytoid 
      dendritic cell neoplasm (BPDCN) due to its expression of characteristic molecules 
      of pDCs. However, we demonstrated that BPDCN is closer to CD56(+) DCs than pDCs 
      by global gene-expression profiling. Thus, we propose that the CD4(+)CD56(+) 
      neoplasm may be a tumor counterpart of CD56(+) mDCs but not pDCs.
FAU - Yu, Haisheng
AU  - Yu H
AD  - Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese 
      Academy of Sciences, Beijing, 100101 China.
AD  - Graduate School of the Chinese Academy of Sciences, Beijing, 100080 China.
FAU - Zhang, Peng
AU  - Zhang P
AD  - Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, 
      Chinese Academy of Sciences, Beijing, 100101 China.
AD  - Graduate School of the Chinese Academy of Sciences, Beijing, 100080 China.
FAU - Yin, Xiangyun
AU  - Yin X
AD  - Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese 
      Academy of Sciences, Beijing, 100101 China.
AD  - Graduate School of the Chinese Academy of Sciences, Beijing, 100080 China.
FAU - Yin, Zhao
AU  - Yin Z
AD  - Department of Cardiology, 306th Hospital of PLA, Beijing, 100101 China.
FAU - Shi, Quanxing
AU  - Shi Q
AD  - Department of Cardiology, 306th Hospital of PLA, Beijing, 100101 China.
FAU - Cui, Ya
AU  - Cui Y
AD  - Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, 
      Chinese Academy of Sciences, Beijing, 100101 China.
FAU - Liu, Guanyuan
AU  - Liu G
AD  - Department of Gynecology and Obstetrics, Beijing Chaoyang Hospital, Capital 
      Medical University, Beijing, 100020 China.
FAU - Wang, Shouli
AU  - Wang S
AD  - Department of Cardiology, 306th Hospital of PLA, Beijing, 100101 China.
FAU - Piccaluga, Pier Paolo
AU  - Piccaluga PP
AD  - Department of Experimental, Diagnostic, and Specialty Medicine, Hematopathology & 
      Hematology Sections, Molecular Pathology Laboratory, S. Orsola-Malpighi Hospital, 
      Bologna University, Bologna, 40126 Italy.
FAU - Jiang, Taijiao
AU  - Jiang T
AD  - Key Laboratory of Protein and Peptide Pharmaceuticals, Institute of Biophysics, 
      Chinese Academy of Sciences, Beijing, 100101 China.
FAU - Zhang, Liguo
AU  - Zhang L
AD  - Key Laboratory of Immunity and Infection, Institute of Biophysics, Chinese 
      Academy of Sciences, Beijing, 100101 China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150318
PL  - Germany
TA  - Protein Cell
JT  - Protein & cell
JID - 101532368
RN  - 0 (Biomarkers)
RN  - 0 (CD56 Antigen)
RN  - 0 (CLEC4C protein, human)
RN  - 0 (IL3RA protein, human)
RN  - 0 (Interferon Type I)
RN  - 0 (Interleukin-3 Receptor alpha Subunit)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (NCAM1 protein, human)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (TLR4 protein, human)
RN  - 0 (TLR7 protein, human)
RN  - 0 (TLR9 protein, human)
RN  - 0 (Toll-Like Receptor 4)
RN  - 0 (Toll-Like Receptor 7)
RN  - 0 (Toll-Like Receptor 9)
RN  - 187348-17-0 (Interleukin-12)
SB  - IM
MH  - Biomarkers/metabolism
MH  - CD56 Antigen/*genetics/immunology
MH  - Cell Lineage/genetics/immunology
MH  - Dendritic Cells/immunology/metabolism/*pathology
MH  - Gene Expression
MH  - Hematologic Neoplasms/genetics/immunology/*pathology
MH  - Humans
MH  - Immunophenotyping
MH  - Interferon Type I/biosynthesis/metabolism
MH  - Interleukin-12/biosynthesis/metabolism
MH  - Interleukin-3 Receptor alpha Subunit/*genetics/immunology
MH  - Lectins, C-Type/*genetics/immunology
MH  - Membrane Glycoproteins/*genetics/immunology
MH  - Myeloid Cells/immunology/metabolism/*pathology
MH  - Receptors, Immunologic/*genetics/immunology
MH  - Terminology as Topic
MH  - Toll-Like Receptor 4/genetics/immunology
MH  - Toll-Like Receptor 7/genetics/immunology
MH  - Toll-Like Receptor 9/genetics/immunology
PMC - PMC4383756
EDAT- 2015/03/18 06:00
MHDA- 2015/12/19 06:00
PMCR- 2015/03/18
CRDT- 2015/03/18 06:00
PHST- 2014/12/10 00:00 [received]
PHST- 2014/12/25 00:00 [accepted]
PHST- 2015/03/18 06:00 [entrez]
PHST- 2015/03/18 06:00 [pubmed]
PHST- 2015/12/19 06:00 [medline]
PHST- 2015/03/18 00:00 [pmc-release]
AID - 140 [pii]
AID - 10.1007/s13238-015-0140-x [doi]
PST - ppublish
SO  - Protein Cell. 2015 Apr;6(4):297-306. doi: 10.1007/s13238-015-0140-x. Epub 2015 
      Mar 18.