PMID- 25780585
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150317
LR  - 20201001
IS  - 2051-4190 (Print)
IS  - 2051-4190 (Electronic)
IS  - 2051-4190 (Linking)
VI  - 24
DP  - 2014
TI  - The emerging role of insulin-like growth factors in testis development and 
      function.
PG  - 12
LID - 10.1186/2051-4190-24-12 [doi]
LID - 12
AB  - The insulin-like family of growth factors (IGFs) - composed of insulin, and 
      insulin-like growth factors I (IGF1) and II (IGF2) - provides essential signals 
      for the control of testis development and function. In the testis, IGFs act in an 
      autocrine-paracrine manner but the extent of their actions has been 
      underestimated due to redundancies at both the ligand and receptor levels, and 
      the perinatal lethality of constitutive knockout mice. This review synthesizes 
      the current understanding of how the IGF system regulates biological processes 
      such as primary sex determination, testis development, spermatogenesis and 
      steroidogenesis, and highlights the questions that remain to be explored.
FAU - Griffeth, Richard J
AU  - Griffeth RJ
AD  - Department of Genetic Medicine and Development, University of Geneva Medical 
      School, 1211 Geneva 4, Switzerland ; iGE3, Institute of Genetics and Genomics of 
      Geneva, University of Geneva, Geneva, Switzerland.
FAU - Bianda, Vanessa
AU  - Bianda V
AD  - Department of Genetic Medicine and Development, University of Geneva Medical 
      School, 1211 Geneva 4, Switzerland ; iGE3, Institute of Genetics and Genomics of 
      Geneva, University of Geneva, Geneva, Switzerland.
FAU - Nef, Serge
AU  - Nef S
AD  - Department of Genetic Medicine and Development, University of Geneva Medical 
      School, 1211 Geneva 4, Switzerland ; iGE3, Institute of Genetics and Genomics of 
      Geneva, University of Geneva, Geneva, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20140818
PL  - England
TA  - Basic Clin Androl
JT  - Basic and clinical andrology
JID - 101640161
PMC - PMC4349729
OTO - NOTNLM
OT  - IGF-I
OT  - IGF-II
OT  - Insulin
OT  - Leydig cells
OT  - Sertoli cells
OT  - Sex determination
OT  - Spermatogenesis
OT  - Testis
EDAT- 2014/01/01 00:00
MHDA- 2014/01/01 00:01
PMCR- 2014/08/18
CRDT- 2015/03/18 06:00
PHST- 2014/06/19 00:00 [received]
PHST- 2014/07/28 00:00 [accepted]
PHST- 2015/03/18 06:00 [entrez]
PHST- 2014/01/01 00:00 [pubmed]
PHST- 2014/01/01 00:01 [medline]
PHST- 2014/08/18 00:00 [pmc-release]
AID - 25 [pii]
AID - 10.1186/2051-4190-24-12 [doi]
PST - epublish
SO  - Basic Clin Androl. 2014 Aug 18;24:12. doi: 10.1186/2051-4190-24-12. eCollection 
      2014.