PMID- 25783157
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20220311
IS  - 1937-9145 (Electronic)
IS  - 1945-0877 (Linking)
VI  - 8
IP  - 368
DP  - 2015 Mar 17
TI  - Interleukin-10-producing CD5+ B cells inhibit mast cells during immunoglobulin 
      E-mediated allergic responses.
PG  - ra28
LID - 10.1126/scisignal.2005861 [doi]
AB  - Subsets of B cells inhibit various immune responses through their production of 
      the cytokine interleukin-10 (IL-10). We found that IL-10-producing CD5(+) B cells 
      suppressed the immunoglobulin E (IgE)- and antigen-mediated activation of mast 
      cells in vitro as well as allergic responses in mice in an IL-10-dependent 
      manner. Furthermore, the suppressive effect of these B cells on mast cells in 
      vitro and in vivo depended on direct cell-to-cell contact through the 
      costimulatory receptor CD40 on CD5(+) B cells and the CD40 ligand on mast cells. 
      This contact enhanced the production of IL-10 by the CD5(+) B cells. Through 
      activation of the Janus-activated kinase-signal transducer and activator of 
      transcription 3 pathway, IL-10 decreased the abundance of the kinases Fyn and Fgr 
      and inhibited the activation of the downstream kinase Syk in mast cells. 
      Together, these findings suggest that an important function of IL-10-producing 
      CD5(+) B cells is inhibiting mast cells and IgE-mediated allergic responses.
CI  - Copyright (c) 2015, American Association for the Advancement of Science.
FAU - Kim, Hyuk Soon
AU  - Kim HS
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Kim, A-Ram
AU  - Kim AR
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Kim, Do Kyun
AU  - Kim DK
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Kim, Hyun Woo
AU  - Kim HW
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Park, Young Hwan
AU  - Park YH
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Jang, Geun Hyo
AU  - Jang GH
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Kim, Bokyung
AU  - Kim B
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Park, Yeong Min
AU  - Park YM
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - You, Jueng Soo
AU  - You JS
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea.
FAU - Kim, Hyung Sik
AU  - Kim HS
AD  - College of Pharmacy, Sungkyunkwan University, Suwon 440-746, Korea.
FAU - Beaven, Michael A
AU  - Beaven MA
AD  - Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, 
      National Institutes of Health, Bethesda, MD 20892, USA.
FAU - Kim, Young Mi
AU  - Kim YM
AD  - College of Pharmacy, Duksung Women's University, Seoul 132-714, Korea.
FAU - Choi, Wahn Soo
AU  - Choi WS
AD  - School of Medicine, Konkuk University, Chungju 380-701, Korea. 
      wahnchoi@kku.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20150317
PL  - United States
TA  - Sci Signal
JT  - Science signaling
JID - 101465400
RN  - 0 (CD40 Antigens)
RN  - 0 (CD5 Antigens)
RN  - 0 (Cd5 protein, mouse)
RN  - 0 (IL10 protein, mouse)
RN  - 0 (Proto-Oncogene Proteins)
RN  - 0 (STAT3 Transcription Factor)
RN  - 0 (Stat3 protein, mouse)
RN  - 130068-27-8 (Interleukin-10)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 2.7.10.2 (Fyn protein, mouse)
RN  - EC 2.7.10.2 (Proto-Oncogene Proteins c-fyn)
RN  - EC 2.7.10.2 (proto-oncogene proteins c-fgr)
RN  - EC 2.7.10.2 (src-Family Kinases)
SB  - IM
MH  - Animals
MH  - B-Lymphocytes/*immunology/pathology
MH  - CD40 Antigens/genetics/immunology
MH  - CD5 Antigens/genetics/*immunology
MH  - Hypersensitivity/genetics/*immunology/pathology
MH  - Immunoglobulin E/genetics/*immunology
MH  - Interleukin-10/genetics/*immunology
MH  - Mast Cells/*immunology/pathology
MH  - Mice
MH  - Mice, Knockout
MH  - Proto-Oncogene Proteins/genetics/immunology
MH  - Proto-Oncogene Proteins c-fyn/genetics/immunology
MH  - STAT3 Transcription Factor/genetics/immunology
MH  - Signal Transduction/genetics/immunology
MH  - src-Family Kinases/genetics/immunology
EDAT- 2015/03/19 06:00
MHDA- 2016/02/05 06:00
CRDT- 2015/03/19 06:00
PHST- 2015/03/19 06:00 [entrez]
PHST- 2015/03/19 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - 8/368/ra28 [pii]
AID - 10.1126/scisignal.2005861 [doi]
PST - epublish
SO  - Sci Signal. 2015 Mar 17;8(368):ra28. doi: 10.1126/scisignal.2005861.