PMID- 25783782
OWN - NLM
STAT- MEDLINE
DCOM- 20151228
LR  - 20150330
IS  - 1098-2302 (Electronic)
IS  - 0012-1630 (Linking)
VI  - 57
IP  - 3
DP  - 2015 Apr
TI  - Decreased Bdnf expression and reduced social behavior in periadolescent rats 
      following prenatal stress.
PG  - 365-73
LID - 10.1002/dev.21297 [doi]
AB  - Prenatal stress (PNS) is a risk factor for the development of neuropsychiatric 
      disorders. This study was aimed at assessing, in a rodent model, changes in gene 
      expression profiles and behavioral output as a result of PNS, during 
      periadolescence, a critical developmental period for the onset of 
      psychopathology. Social behavior was studied in a standardized social interaction 
      paradigm and the expression of Brain-Derived Neurotrophic Factor (Bdnf), a marker 
      of neuronal plasticity, and of inhibitory and excitatory mechanisms 
      (Na(+)-K(+)-2Cl(-) and K(+)-Cl(-) cotransporters ratio, NKCC1/KCC2) was analyzed. 
      Results indicate that PNS reduced Bdnf transcripts while increasing the 
      NKCC1/KCC2 ratio, primarily in the hippocampus. In the prefrontal cortex, changes 
      in Bdnf were found to be gender-dependent. These effects were accompanied by 
      reduced levels of affiliative and investigative social behaviors. Interestingly, 
      interaction with non-stressed subjects was able to improve sociality in PNS rats 
      suggesting that the social environment could be exploited for therapeutic 
      intervention.
CI  - (c) 2015 Wiley Periodicals, Inc.
FAU - Berry, Alessandra
AU  - Berry A
AD  - Department of Cell Biology and Neurosciences, Section of Behavioral Neuroscience, 
      Istituto Superiore di Sanita, Viale Regina Elena 299, Rome, 00161, Italy.
FAU - Panetta, Pamela
AU  - Panetta P
FAU - Luoni, Alessia
AU  - Luoni A
FAU - Bellisario, Veronica
AU  - Bellisario V
FAU - Capoccia, Sara
AU  - Capoccia S
FAU - Riva, Marco Andrea
AU  - Riva MA
FAU - Cirulli, Francesca
AU  - Cirulli F
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150318
PL  - United States
TA  - Dev Psychobiol
JT  - Developmental psychobiology
JID - 0164074
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Analysis of Variance
MH  - Animals
MH  - Behavior, Animal/*physiology
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Disease Models, Animal
MH  - Female
MH  - Gene Expression/genetics
MH  - Male
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*genetics/psychology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Real-Time Polymerase Chain Reaction
MH  - *Social Behavior
MH  - Stress, Physiological/*genetics
MH  - Stress, Psychological/*genetics/physiopathology
OTO - NOTNLM
OT  - Bdnf
OT  - gene expression
OT  - hippocampus
OT  - periadolescence
OT  - prefrontal cortex
OT  - prenatal stress
OT  - rats
OT  - social behavior
EDAT- 2015/03/19 06:00
MHDA- 2015/12/29 06:00
CRDT- 2015/03/19 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2015/01/19 00:00 [accepted]
PHST- 2015/03/19 06:00 [entrez]
PHST- 2015/03/19 06:00 [pubmed]
PHST- 2015/12/29 06:00 [medline]
AID - 10.1002/dev.21297 [doi]
PST - ppublish
SO  - Dev Psychobiol. 2015 Apr;57(3):365-73. doi: 10.1002/dev.21297. Epub 2015 Mar 18.