PMID- 25783889
OWN - NLM
STAT- MEDLINE
DCOM- 20151204
LR  - 20220410
IS  - 1643-3750 (Electronic)
IS  - 1234-1010 (Print)
IS  - 1234-1010 (Linking)
VI  - 21
DP  - 2015 Mar 18
TI  - Efficiency and safety of pulmonary rehabilitation in acute exacerbation of 
      chronic obstructive pulmonary disease.
PG  - 806-12
LID - 10.12659/MSM.892769 [doi]
AB  - BACKGROUND: Pulmonary rehabilitation (PR) is able to improve dyspnea, endurance 
      capacity, and health-related quality of life in chronic obstructive pulmonary 
      disease (COPD) patients, but it is rarely used in China. This study aimed to 
      assess the effectiveness and safety of PR after exacerbation of COPD. MATERIAL 
      AND METHODS: Patients admitted to hospital due to an exacerbation of COPD were 
      randomized to receive either PR or routine care (control group). The PR program 
      was performed from the second day of admission until discharge. The pre-post 
      changes in 6-minute walk distance (6MWD), self-reported quality of life (QOL) 
      assessed by CAT score and CRQ-SAS score, and activity of daily life assessed by 
      ADL-D score were determined. The perceived end-effort dyspnea (Borg scale) was 
      measured throughout the study. RESULTS: A total of 101 patients were enrolled, of 
      whom 7 withdrew after randomization, and 94 completed this study. There were 66 
      patients in the PR group and 28 in the control group. The 6MWD, resting SpO2, and 
      exercise Borg dyspnea score were significantly improved in the PR group. In 
      addition, the PR group had greater improvement in the total CRQ-SAS score and had 
      a lower CAT score. Significant improvements were also found in the ADL-D and BODE 
      index in the PR group. No adverse events were recorded during exercise. 
      CONCLUSIONS: Our study provides evidence that it is safe and feasible to apply an 
      early PR in patients with acute exacerbation of COPD.
FAU - He, Mei
AU  - He M
AD  - Department of Respiratory Medicine, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China (mainland).
FAU - Yu, Sue
AU  - Yu S
AD  - Department of Respiratory Medicine, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China (mainland).
FAU - Wang, Lemin
AU  - Wang L
AD  - Department of Cardiology, Tongji Hospital, Tongji University School of Medicine, 
      Shanghai, China (mainland).
FAU - Lv, Hanjing
AU  - Lv H
AD  - Department of Respiratory Medicine, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China (mainland).
FAU - Qiu, Zhongmin
AU  - Qiu Z
AD  - Department of Respiratory Medicine, Tongji Hospital, Tongji University School of 
      Medicine, Shanghai, China (mainland).
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
DEP - 20150318
PL  - United States
TA  - Med Sci Monit
JT  - Medical science monitor : international medical journal of experimental and 
      clinical research
JID - 9609063
SB  - IM
MH  - Activities of Daily Living
MH  - Aged
MH  - *Disease Progression
MH  - Dyspnea/pathology
MH  - Exercise
MH  - Female
MH  - Humans
MH  - Lung/*pathology
MH  - Male
MH  - Pulmonary Disease, Chronic Obstructive/*pathology/*rehabilitation
MH  - Quality of Life
MH  - Walking
PMC - PMC4374486
EDAT- 2015/03/19 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/03/18
CRDT- 2015/03/19 06:00
PHST- 2015/03/19 06:00 [entrez]
PHST- 2015/03/19 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/03/18 00:00 [pmc-release]
AID - 892769 [pii]
AID - 10.12659/MSM.892769 [doi]
PST - epublish
SO  - Med Sci Monit. 2015 Mar 18;21:806-12. doi: 10.12659/MSM.892769.