PMID- 25784293
OWN - NLM
STAT- MEDLINE
DCOM- 20160509
LR  - 20181113
IS  - 1531-135X (Electronic)
IS  - 1530-7026 (Print)
IS  - 1530-7026 (Linking)
VI  - 15
IP  - 3
DP  - 2015 Sep
TI  - Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with 
      hippocampal volume and memory.
PG  - 625-43
LID - 10.3758/s13415-015-0343-x [doi]
AB  - Brain-derived neurotrophic factor (BDNF) has been shown to be important for 
      neuronal survival and synaptic plasticity in the hippocampus in nonhuman animals. 
      The Val66Met polymorphism in the BDNF gene, involving a valine (Val) to 
      methionine (Met) substitution at codon 66, has been associated with lower BDNF 
      secretion in vitro. However, there have been mixed results regarding associations 
      between either circulating BDNF or the BDNF Val66Met polymorphism with 
      hippocampal volume and memory in humans. The current study examined the 
      association of BDNF genotype and plasma BDNF with hippocampal volume and memory 
      in two large independent cohorts of middle-aged and older adults (both 
      cognitively normal and early-stage dementia). Sample sizes ranged from 123 to 
      649. Measures of the BDNF genotype, plasma BDNF, MRI-based hippocampal volume, 
      and memory performance were obtained from the Knight Alzheimer Disease Research 
      Center (ADRC) and the Alzheimer's Disease Neuroimaging Initiative (ADNI). There 
      were no significant differences between BDNF Met+ and Met- groups on either 
      hippocampal volume or memory in either cohort. In addition, plasma BDNF was not 
      significantly associated with either hippocampal volume or memory in either 
      cohort. Neither age, cognitive status, nor gender moderated any of the 
      relationships. Overall, current findings suggest that BDNF genotype and plasma 
      BDNF may not be robust predictors for variance in hippocampal volume and memory 
      in middle age and older adult cohorts.
FAU - Kim, Ana
AU  - Kim A
AD  - Program in Neuroscience, Division of Biology and Biomedical Sciences, Washington 
      University, St. Louis, MO, USA.
FAU - Fagan, Anne M
AU  - Fagan AM
FAU - Goate, Alison M
AU  - Goate AM
FAU - Benzinger, Tammie L S
AU  - Benzinger TL
FAU - Morris, John C
AU  - Morris JC
FAU - Head, Denise
AU  - Head D
CN  - Alzheimer's Disease Neuroimaging Initiative
LA  - eng
GR  - P50 AG05861/AG/NIA NIH HHS/United States
GR  - U01 AG024904/AG/NIA NIH HHS/United States
GR  - P01 AG003991/AG/NIA NIH HHS/United States
GR  - P50 AG005681/AG/NIA NIH HHS/United States
GR  - P01 AG026276/AG/NIA NIH HHS/United States
GR  - P01 AG03991/AG/NIA NIH HHS/United States
GR  - P30 NS098577/NS/NINDS NIH HHS/United States
GR  - P30 NS048056/NS/NINDS NIH HHS/United States
GR  - UL1 TR000448/TR/NCATS NIH HHS/United States
GR  - T32 AG000030/AG/NIA NIH HHS/United States
GR  - F32 AG005861/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cogn Affect Behav Neurosci
JT  - Cognitive, affective & behavioral neuroscience
JID - 101083946
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Aged
MH  - Aging/blood/genetics/pathology/psychology
MH  - Association Learning/physiology
MH  - Brain-Derived Neurotrophic Factor/*blood/*genetics
MH  - Cohort Studies
MH  - Dementia/genetics/pathology/psychology
MH  - Female
MH  - Genotyping Techniques
MH  - Hippocampus/*anatomy & histology/pathology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory/*physiology
MH  - Organ Size
MH  - *Polymorphism, Single Nucleotide
MH  - Psychological Tests
MH  - Sex Characteristics
PMC - PMC4529376
MID - NIHMS673156
COIS- The authors have no conflicts of interest related to this work.
EDAT- 2015/03/19 06:00
MHDA- 2016/05/10 06:00
PMCR- 2016/09/01
CRDT- 2015/03/19 06:00
PHST- 2015/03/19 06:00 [entrez]
PHST- 2015/03/19 06:00 [pubmed]
PHST- 2016/05/10 06:00 [medline]
PHST- 2016/09/01 00:00 [pmc-release]
AID - 10.3758/s13415-015-0343-x [doi]
PST - ppublish
SO  - Cogn Affect Behav Neurosci. 2015 Sep;15(3):625-43. doi: 
      10.3758/s13415-015-0343-x.