PMID- 25784940
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150318
LR  - 20201001
IS  - 1687-966X (Print)
IS  - 1687-9678 (Electronic)
VI  - 2015
DP  - 2015
TI  - Immune suppressive effects of tonsil-derived mesenchymal stem cells on mouse 
      bone-marrow-derived dendritic cells.
PG  - 106540
LID - 10.1155/2015/106540 [doi]
LID - 106540
AB  - Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy 
      because of their immune regulatory function. Here, we investigated the effects of 
      tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of 
      dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and 
      maturation of bone-marrow- (BM-) derived monocytes into DCs and we found 
      suppressive effect of T-MSCs on DCs via direct contact as well as soluble 
      mediators. Moreover, T cell proliferation, normally increased in the presence of 
      DCs, was inhibited by T-MSCs. Differentiation of CD4(+) T cell subsets by the 
      DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators 
      suppressed by T-MSCs were granulocyte-macrophage colony-stimulating factor 
      (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 
      (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression 
      of the differentiation, maturation, and function of BM-derived DCs. Our data 
      suggests that T-MSCs could be used as a novel source of stem cell therapy as 
      immune modulators.
FAU - Park, Minhwa
AU  - Park M
AUID- ORCID: 0000-0001-5732-6915
AD  - Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 
      158-710, Republic of Korea.
FAU - Kim, Yu-Hee
AU  - Kim YH
AUID- ORCID: 0000-0002-7804-9264
AD  - Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 
      158-710, Republic of Korea.
FAU - Ryu, Jung-Hwa
AU  - Ryu JH
AUID- ORCID: 0000-0003-1887-7823
AD  - Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 
      158-710, Republic of Korea.
FAU - Woo, So-Youn
AU  - Woo SY
AUID- ORCID: 0000-0001-6902-0315
AD  - Department of Microbiology, School of Medicine, Ewha Womans University, Seoul 
      158-710, Republic of Korea.
FAU - Ryu, Kyung-Ha
AU  - Ryu KH
AD  - Department of Pediatrics, School of Medicine, Ewha Womans University, Seoul 
      158-710, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20150216
PL  - United States
TA  - Stem Cells Int
JT  - Stem cells international
JID - 101535822
EIN - Stem Cells Int. 2019 Mar 5;2019:9071046. PMID: 30949211
PMC - PMC4345276
EDAT- 2015/03/19 06:00
MHDA- 2015/03/19 06:01
PMCR- 2015/02/16
CRDT- 2015/03/19 06:00
PHST- 2014/11/21 00:00 [received]
PHST- 2015/01/09 00:00 [revised]
PHST- 2015/01/24 00:00 [accepted]
PHST- 2015/03/19 06:00 [entrez]
PHST- 2015/03/19 06:00 [pubmed]
PHST- 2015/03/19 06:01 [medline]
PHST- 2015/02/16 00:00 [pmc-release]
AID - 10.1155/2015/106540 [doi]
PST - ppublish
SO  - Stem Cells Int. 2015;2015:106540. doi: 10.1155/2015/106540. Epub 2015 Feb 16.