PMID- 25785011
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150318
LR  - 20201001
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 1
DP  - 2015
TI  - Neural stem cells transplantation alleviate the hyperalgesia of spinal cord 
      injured (SCI) associated with down-regulation of BDNF.
PG  - 404-12
AB  - Transplantation of neural stem cells (NSCs) in the injured spinal cord has been 
      shown to improve functional outcome. However, the influence of NSCs 
      transplantation on the sensory function and analgesic behaviors has not been 
      elucidated yet. Here, we investigated whether transplanted NSCs would improve 
      sensory function in rats subjected to complete cord transection (T10) and explore 
      the underlying mechanism. The rats were divided into sham, SCT (spinal cord 
      transection), and NSC implanted groups. NSCs (3 x 10(6)/ml) were implanted into 
      injury site at the day after operation. Mechanical (the hind paw test) and 
      thermal (the tail-flick test) were measured at 5 weeks. Immunohistochemistry and 
      RT-PCR were used to demonstrate that expression of Brain-derived neurotrophic 
      factor (BDNF) in the superficial of the dorsal horn. Consequently, the tail-flick 
      latencies and paw withdrawal thresholds in NSC implanted group exhibit a 
      significant higher than SCT group (P < 0.05). RT-PCR demonstrate that mRNA 
      expression of BDNF was down-regulated remarkably in NSC engrafted rats. The 
      present findings suggest that NSC transplantation inhibits neuropathic pain 
      associated with BDNF down-regulation.
FAU - Yao, Zhi-Gang
AU  - Yao ZG
AD  - Department of Neurosurgery, The Third Hospital of Shijiazhuang City Shijiazhuang 
      050011, Hebei, P.R. China.
FAU - Sun, Xiao-Li
AU  - Sun XL
AD  - Department of Neurosurgery, The Third Hospital of Shijiazhuang City Shijiazhuang 
      050011, Hebei, P.R. China.
FAU - Li, Peng
AU  - Li P
AD  - Department of Neurosurgery, The Third Hospital of Shijiazhuang City Shijiazhuang 
      050011, Hebei, P.R. China.
FAU - Liu, Hong-Lei
AU  - Liu HL
AD  - Department of Neurosurgery, The Third Hospital of Shijiazhuang City Shijiazhuang 
      050011, Hebei, P.R. China.
FAU - Wu, Hai-Long
AU  - Wu HL
AD  - Department of Neurosurgery, The Third Hospital of Shijiazhuang City Shijiazhuang 
      050011, Hebei, P.R. China.
FAU - Xi, Zhi-Qiang
AU  - Xi ZQ
AD  - Department of Neurosurgery, The Third Hospital of Shijiazhuang City Shijiazhuang 
      050011, Hebei, P.R. China.
FAU - Zheng, Zhong-Hui
AU  - Zheng ZH
AD  - Department of Neurosurgery, The Third Hospital of Shijiazhuang City Shijiazhuang 
      050011, Hebei, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20150115
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4358466
OTO - NOTNLM
OT  - BDNF
OT  - NSC
OT  - rat
OT  - sensory function
OT  - spinal cord transaction
EDAT- 2015/03/19 06:00
MHDA- 2015/03/19 06:01
PMCR- 2015/01/15
CRDT- 2015/03/19 06:00
PHST- 2014/10/10 00:00 [received]
PHST- 2015/01/05 00:00 [accepted]
PHST- 2015/03/19 06:00 [entrez]
PHST- 2015/03/19 06:00 [pubmed]
PHST- 2015/03/19 06:01 [medline]
PHST- 2015/01/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Jan 15;8(1):404-12. eCollection 2015.