PMID- 25785055
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150318
LR  - 20201001
IS  - 1940-5901 (Print)
IS  - 1940-5901 (Electronic)
IS  - 1940-5901 (Linking)
VI  - 8
IP  - 1
DP  - 2015
TI  - The roles of vitamin B12 and vitamin D in children with intractable epilepsy.
PG  - 764-9
AB  - Epilepsy is a chronic neurological disorder. Antiepileptic drugs (AEDs) can cause 
      vitamin B12 or D deficiency in children with intractable epilepsy. In this study, 
      we measured salivary superoxide dismutase (SOD) and metalloproteinsases (MMP) 
      levels in the patients with vitamin B12 and vitamin D treatment. Cytokines and 
      chemokines were measured using ELISA. The mean salivary value of SOD activity in 
      the control group was 1.75 +/- 0.21 U/ml. In the treatment group, the value was 
      1.33 +/- 0.18 U/ml. The salivary MMP 2, MMP 3, and MMP 9 levels of the patients 
      with vitamin D and vitamin B12 treatment were lower than that in the patients 
      without vitamin D and vitamin B12 treatment. Interleukin 1beta (IL-1beta), IL-6, IL-8, 
      macrophage inflammatory protein 1beta (MIP-1beta), monocyte chemoattractant protein-1 
      (MCP-1) and IFN-inducible protein 10 (IP-10) were significantly decreased in the 
      cortex of our patients with vitamin D and vitamin B12 treatment. In this study, a 
      clear association between vitamin D and vitamin B12 treatment and epilepsy was 
      identified. We now plan to investigate the genetic factors that underlie vitamin 
      D and vitamin B12 treatment in patients treated with AEDs.
FAU - Li, Xiao-Hong
AU  - Li XH
AD  - Department of Neurology, The First Hospital of China Medical University Nanjing 
      North Street 155, Heping District, Shenyang City 110001, Liaoning Province, 
      China.
FAU - Hou, Xiao-Yan
AU  - Hou XY
AD  - Department of Paediatrics, The First Hospital of Qiqihaer City Park Road 30, 
      Qiqihaer City 161000, Heilongjiang Province, China.
FAU - Chen, Rong
AU  - Chen R
AD  - Department of Neurology, The First Hospital of China Medical University Nanjing 
      North Street 155, Heping District, Shenyang City 110001, Liaoning Province, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20150115
PL  - United States
TA  - Int J Clin Exp Med
JT  - International journal of clinical and experimental medicine
JID - 101471010
PMC - PMC4358510
OTO - NOTNLM
OT  - MMP
OT  - Vitamin D
OT  - antiepileptic drugs
OT  - cytokines
OT  - vitamin B12
EDAT- 2015/03/19 06:00
MHDA- 2015/03/19 06:01
PMCR- 2015/01/15
CRDT- 2015/03/19 06:00
PHST- 2014/11/02 00:00 [received]
PHST- 2015/01/07 00:00 [accepted]
PHST- 2015/03/19 06:00 [entrez]
PHST- 2015/03/19 06:00 [pubmed]
PHST- 2015/03/19 06:01 [medline]
PHST- 2015/01/15 00:00 [pmc-release]
PST - epublish
SO  - Int J Clin Exp Med. 2015 Jan 15;8(1):764-9. eCollection 2015.