PMID- 25786118 OWN - NLM STAT- MEDLINE DCOM- 20160205 LR - 20181113 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 10 IP - 3 DP - 2015 TI - Serum levels of monocyte chemoattractant protein-1 and all-cause and cardiovascular mortality among patients with coronary artery disease. PG - e0120633 LID - 10.1371/journal.pone.0120633 [doi] LID - e0120633 AB - BACKGROUND: Monocyte chemoattractant protein-1 (MCP-1) is an important chemokine at multiple phases of atherosclerosis in animals, but human studies are few and inconsistent. The aim of this study is to investigate the association of serum MCP-1 with all-cause and cardiovascular disease (CVD) mortality among coronary artery disease (CAD) patients and determine whether this biomarker can add secondary prognostic value to standard risk predictors. METHODS: MCP-1 was measured at baseline in 1411 CAD patients who were 40-85 years of age. Cox proportional hazards regression models were used to estimate the association of MCP-1 levels with death risk. RESULTS: During a median follow-up of 3.3 years, 117 deaths were recorded, 88 of which were due to CVD. The multivariable-adjusted hazard ratios across tertiles of MCP-1 were 1.51 (95% confidence intervals [CI] 0.89-2.58), 1.00, and 2.11 (95% CI 1.31-3.40) for all-cause mortality, and 1.50 (95% CI 0.80-2.81), 1.00, and 2.21 (95% CI 1.27-3.87) for CVD mortality. The addition of serum MCP-1 to the fully adjusted model increased the C-index by 0.009 (p<0.0001) for all-cause mortality and 0.008 (p<0.0001) for CVD mortality and significantly improved the predictive ability by 12.1% (P = 0.006) on all-cause mortality and 12.6% (P = 0.003) on CVD mortality using the net reclassification improvement method. CONCLUSIONS: Both lower and higher MCP-1 levels are associated with an increased risk of all-cause and CVD mortality among CAD patients. More research is needed to confirm its clinical relevance. FAU - Ding, Ding AU - Ding D AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China; Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America. FAU - Su, Dongfang AU - Su D AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Li, Xinrui AU - Li X AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Li, Zhongxia AU - Li Z AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Wang, Yujie AU - Wang Y AD - Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America. FAU - Qiu, Jian AU - Qiu J AD - Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong, China. FAU - Lin, Puqing AU - Lin P AD - Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong, China. FAU - Zhang, Yuan AU - Zhang Y AD - Department of Cardiology, General Hospital of Guangzhou Military Command of People's Liberation Army, Guangdong, China. FAU - Guo, Pi AU - Guo P AD - Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Xia, Min AU - Xia M AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Li, Dan AU - Li D AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Yang, Yan AU - Yang Y AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. FAU - Hu, Gang AU - Hu G AD - Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America. FAU - Ling, Wenhua AU - Ling W AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20150318 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Biomarkers) RN - 0 (CCL2 protein, human) RN - 0 (Chemokine CCL2) SB - IM MH - Adult MH - Age Factors MH - Aged MH - Aged, 80 and over MH - Biomarkers/blood MH - Chemokine CCL2/*blood/genetics MH - Coronary Artery Disease/*blood/diagnosis/mortality/physiopathology MH - Female MH - Gene Expression MH - Humans MH - Male MH - Middle Aged MH - Prognosis MH - Prospective Studies MH - Risk Factors MH - Survival Analysis PMC - PMC4365005 COIS- Competing Interests: The authors have declared that no competing interests exist. EDAT- 2015/03/19 06:00 MHDA- 2016/02/06 06:00 PMCR- 2015/03/18 CRDT- 2015/03/19 06:00 PHST- 2014/07/22 00:00 [received] PHST- 2015/01/27 00:00 [accepted] PHST- 2015/03/19 06:00 [entrez] PHST- 2015/03/19 06:00 [pubmed] PHST- 2016/02/06 06:00 [medline] PHST- 2015/03/18 00:00 [pmc-release] AID - PONE-D-14-32835 [pii] AID - 10.1371/journal.pone.0120633 [doi] PST - epublish SO - PLoS One. 2015 Mar 18;10(3):e0120633. doi: 10.1371/journal.pone.0120633. eCollection 2015.