PMID- 25786566
OWN - NLM
STAT- MEDLINE
DCOM- 20161114
LR  - 20221207
IS  - 1943-3670 (Electronic)
IS  - 0022-3492 (Linking)
VI  - 86
IP  - 6
DP  - 2015 Jun
TI  - Effect of non-surgical periodontal treatment on visfatin concentrations in serum 
      and gingival crevicular fluid of patients with chronic periodontitis and type 2 
      diabetes mellitus.
PG  - 795-800
LID - 10.1902/jop.2015.140476 [doi]
AB  - BACKGROUND: This study aims to assess visfatin concentrations in serum and 
      gingival crevicular fluid (GCF) and investigate this relationship in patients 
      with type 2 diabetes mellitus (T2DM) and chronic periodontitis (CP) before and 
      after non-surgical periodontal treatment. METHODS: Fifty-four patients with T2DM 
      and CP were recruited. The patients were randomly divided into two groups: 
      treatment and control. Serum and GCF visfatin concentrations and glycated 
      hemoglobin (HbA1c) levels were measured by enzyme-linked immunosorbent assay at 
      different time points (at baseline and 3 and 6 months after non-surgical 
      periodontal treatment). RESULTS: Serum and GCF visfatin concentrations showed no 
      significant differences between the groups at baseline (t test, P >0.05). A 
      significant decline of visfatin in the treatment group was found in serum and GCF 
      3 months after non-surgical periodontal treatment (t test, P <0.01). Baseline and 
      3-month HbA1c levels were not significantly different, but at 6 months, a 
      statistically significant difference was detected (t test, P >0.05). CONCLUSIONS: 
      The data suggest that non-surgical periodontal treatment is helpful for glucose 
      control, an effect that may be associated with reduced visfatin in patients with 
      T2DM and periodontitis. Furthermore, the data suggest that visfatin may be 
      considered an inflammatory marker for periodontal diseases.
FAU - Wu, Yun
AU  - Wu Y
AD  - *School of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.
AD  - daggerDepartment of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China.
FAU - Chen, Ling
AU  - Chen L
AD  - daggerDepartment of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China.
FAU - Wei, Bin
AU  - Wei B
AD  - daggerDepartment of Stomatology, The First Affiliated Hospital of Fujian Medical 
      University, Fuzhou, Fujian, China.
FAU - Luo, Kai
AU  - Luo K
AD  - *School of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.
FAU - Yan, Fuhua
AU  - Yan F
AD  - *School of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.
AD  - double daggerNangjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 
      Jiangsu, China.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20150319
PL  - United States
TA  - J Periodontol
JT  - Journal of periodontology
JID - 8000345
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Cytokines)
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Inflammation Mediators)
RN  - EC 2.4.2.12 (Nicotinamide Phosphoribosyltransferase)
RN  - EC 2.4.2.12 (nicotinamide phosphoribosyltransferase, human)
SB  - IM
MH  - Biomarkers/analysis/blood
MH  - Blood Glucose/analysis
MH  - Chronic Periodontitis/*blood/metabolism/therapy
MH  - Cytokines/analysis/*blood
MH  - Diabetes Mellitus, Type 2/*blood/metabolism
MH  - Female
MH  - Follow-Up Studies
MH  - Gingival Crevicular Fluid/*chemistry
MH  - Glycated Hemoglobin/analysis
MH  - Humans
MH  - Inflammation Mediators/analysis/blood
MH  - Male
MH  - Middle Aged
MH  - Nicotinamide Phosphoribosyltransferase/analysis/*blood
MH  - Oral Hygiene/education
MH  - Periodontal Attachment Loss/blood/metabolism/therapy
MH  - Periodontal Debridement/*methods
MH  - Periodontal Index
MH  - Periodontal Pocket/blood/metabolism/therapy
OTO - NOTNLM
OT  - Adipokines
OT  - chronic periodontitis
OT  - diabetes mellitus
OT  - gingival crevicular fluid
OT  - nicotinamide phosphoribosyltransferase
OT  - nonsurgical periodontal debridement
EDAT- 2015/03/20 06:00
MHDA- 2016/11/15 06:00
CRDT- 2015/03/20 06:00
PHST- 2015/03/20 06:00 [entrez]
PHST- 2015/03/20 06:00 [pubmed]
PHST- 2016/11/15 06:00 [medline]
AID - 10.1902/jop.2015.140476 [doi]
PST - ppublish
SO  - J Periodontol. 2015 Jun;86(6):795-800. doi: 10.1902/jop.2015.140476. Epub 2015 
      Mar 19.