PMID- 25787095
OWN - NLM
STAT- MEDLINE
DCOM- 20160219
LR  - 20150520
IS  - 1742-2051 (Electronic)
IS  - 1742-2051 (Linking)
VI  - 11
IP  - 6
DP  - 2015 Jun
TI  - Molecular effects of supraphysiological doses of doping agents on health.
PG  - 1494-506
LID - 10.1039/c5mb00030k [doi]
AB  - Performance-enhancing drugs (PEDs) gained wide popularity not only among 
      sportsmen but also among specific subsets of population, such as adolescents. 
      Apart from their claimed effects on athletic performance, they are very appealing 
      due to the body shaping effect exerted on fat mass and fat-free mass. Besides the 
      "underestimated" massive misuse of PEDs, the short- as well as long-term 
      consequences of such habits remain largely unrecognized. They have been strictly 
      associated with serious adverse effects, but molecular mechanisms are yet to be 
      elucidated. Here, we analyze the current understanding of the molecular effects 
      of supraphysiological doses of doping agents in healthy biological systems, at 
      genomic and proteomic levels, in order to define the molecular sensors of 
      organ/tissue impairment, determined by their misuse. The focus is put on the 
      anabolic androgenic steroids (AASs), specifically testosterone (T) and its most 
      potent derivative dihydrotestosterone (DHT), and on the peptide hormones, 
      specifically the growth hormone (GH) and the insulin-like growth factor-1 
      (IGF-1). A map of molecular targets is defined and the risk incidence for human 
      health is taken into account.
FAU - Imperlini, Esther
AU  - Imperlini E
AD  - IRCCS SDN, Naples, Italy.
FAU - Mancini, Annamaria
AU  - Mancini A
FAU - Alfieri, Andreina
AU  - Alfieri A
FAU - Martone, Domenico
AU  - Martone D
FAU - Caterino, Marianna
AU  - Caterino M
FAU - Orru, Stefania
AU  - Orru S
FAU - Buono, Pasqualina
AU  - Buono P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Mol Biosyst
JT  - Molecular bioSystems
JID - 101251620
RN  - 0 (Biomarkers)
RN  - 3XMK78S47O (Testosterone)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Apoptosis/drug effects
MH  - Biomarkers/analysis/chemistry
MH  - *Doping in Sports
MH  - Growth Hormone/adverse effects/*pharmacology
MH  - Humans
MH  - Proteomics
MH  - Signal Transduction/drug effects
MH  - Testosterone/adverse effects/*pharmacology
EDAT- 2015/03/20 06:00
MHDA- 2016/02/20 06:00
CRDT- 2015/03/20 06:00
PHST- 2015/03/20 06:00 [entrez]
PHST- 2015/03/20 06:00 [pubmed]
PHST- 2016/02/20 06:00 [medline]
AID - 10.1039/c5mb00030k [doi]
PST - ppublish
SO  - Mol Biosyst. 2015 Jun;11(6):1494-506. doi: 10.1039/c5mb00030k.