PMID- 25787953
OWN - NLM
STAT- MEDLINE
DCOM- 20160315
LR  - 20181113
IS  - 1522-1598 (Electronic)
IS  - 0022-3077 (Print)
IS  - 0022-3077 (Linking)
VI  - 113
IP  - 10
DP  - 2015 Jun 1
TI  - Assessment of nonlinear interactions in event-related potentials elicited by 
      stimuli presented at short interstimulus intervals using single-trial data.
PG  - 3623-33
LID - 10.1152/jn.00523.2014 [doi]
AB  - The recording of brain event-related potentials (ERPs) is a widely used technique 
      to investigate the neural basis of sensory perception and cognitive processing in 
      humans. Due to the low magnitude of ERPs, averaging of several consecutive 
      stimuli is typically employed to enhance the signal to noise ratio (SNR) before 
      subsequent analysis. However, when the temporal interval between two consecutive 
      stimuli is smaller than the latency of the main ERP peaks, i.e., when the stimuli 
      are presented at a fast rate, overlaps between the corresponding ERPs may occur. 
      These overlaps are usually dealt with by assuming that there is a simple additive 
      superposition between the elicited ERPs and consequently performing algebraic 
      waveform subtractions. Here, we test this assumption rigorously by providing a 
      statistical framework that examines the presence of nonlinear additive effects 
      between overlapping ERPs elicited by successive stimuli with short interstimulus 
      intervals (ISIs). The results suggest that there are no nonlinear additive 
      effects due to the time overlap per se but that, for the range of ISIs examined, 
      the second ERP is modulated by the presence of the first stimulus irrespective of 
      whether there is time overlap or not. In other words, two ERPs that overlap in 
      time can still be written as an addition of two ERPs but with the second ERP 
      being different from the first. This difference is also present in the case of 
      nonoverlapping ERPs with short ISIs. The modulation effect elicited on the second 
      ERP by the first stimulus is dependent on the ISI value.
CI  - Copyright (c) 2015 the American Physiological Society.
FAU - Loizides, Charalambos
AU  - Loizides C
AD  - KIOS Research Center for Intelligent Systems and Networks, University of Cyprus, 
      Nicosia, Cyprus;
FAU - Achilleos, Achilleas
AU  - Achilleos A
AD  - KIOS Research Center for Intelligent Systems and Networks, University of Cyprus, 
      Nicosia, Cyprus; Cancer Research United Kingdom Cambridge Institute, University 
      of Cambridge, Cambridge, United Kingdom;
FAU - Iannetti, Gian Domenico
AU  - Iannetti GD
AD  - Department of Neuroscience, Physiology and Pharmacology, University College 
      London, London, United Kingdom; and.
FAU - Mitsis, Georgios D
AU  - Mitsis GD
AD  - KIOS Research Center for Intelligent Systems and Networks, University of Cyprus, 
      Nicosia, Cyprus; Department of Bioengineering, McGill University, Montreal, 
      Canada georgios.mitsis@mcgill.ca.
LA  - eng
GR  - 102645/Wellcome Trust/United Kingdom
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150318
PL  - United States
TA  - J Neurophysiol
JT  - Journal of neurophysiology
JID - 0375404
SB  - IM
MH  - Adult
MH  - Analysis of Variance
MH  - Biophysics
MH  - Electroencephalography
MH  - Evoked Potentials/*physiology
MH  - Female
MH  - Fourier Analysis
MH  - Healthy Volunteers
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Nonlinear Dynamics
MH  - Time Factors
MH  - Young Adult
PMC - PMC4461881
OTO - NOTNLM
OT  - EEG
OT  - ERP
OT  - analysis of variance
OT  - mixed effects models
EDAT- 2015/03/20 06:00
MHDA- 2016/03/16 06:00
PMCR- 2016/06/01
CRDT- 2015/03/20 06:00
PHST- 2014/07/16 00:00 [received]
PHST- 2015/03/17 00:00 [accepted]
PHST- 2015/03/20 06:00 [entrez]
PHST- 2015/03/20 06:00 [pubmed]
PHST- 2016/03/16 06:00 [medline]
PHST- 2016/06/01 00:00 [pmc-release]
AID - jn.00523.2014 [pii]
AID - JN-00523-2014 [pii]
AID - 10.1152/jn.00523.2014 [doi]
PST - ppublish
SO  - J Neurophysiol. 2015 Jun 1;113(10):3623-33. doi: 10.1152/jn.00523.2014. Epub 2015 
      Mar 18.