PMID- 25788880
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150319
LR  - 20201001
IS  - 1662-5153 (Print)
IS  - 1662-5153 (Electronic)
IS  - 1662-5153 (Linking)
VI  - 9
DP  - 2015
TI  - Dorsal periaqueductal gray simultaneously modulates ventral subiculum 
      induced-plasticity in the basolateral amygdala and the nucleus accumbens.
PG  - 53
LID - 10.3389/fnbeh.2015.00053 [doi]
LID - 53
AB  - The ventral subiculum of the hippocampus projects both to the basolateral 
      amygdala (BLA), which is typically, associated with a response to aversive 
      stimuli, as well as to the nucleus accumbens (NAcc), which is typically 
      associated with a response to appetitive stimuli. Traditionally, studies of the 
      responses to emotional events focus on either negative or positive affect-related 
      processes, however, emotional experiences often affect both. The ability of 
      high-level processing brain regions (e.g., medial prefrontal cortex) to modulate 
      the balance between negative and positive affect-related regions was examined 
      extensively. In contrast, the ability of low-level processing areas (e.g., 
      periaqueductal gray-PAG) to do so, has not been sufficiently studied. To address 
      whether midbrain structures have the ability to modulate limbic regions, we first 
      examined the ventral subiculum stimulation's (vSub) ability to induce plasticity 
      in the BLA and NAcc simultaneously in rats. Further, dorsal PAG (dPAG) priming 
      ability to differentially modulate vSub stimulation induced plasticity in the BLA 
      and the NAcc was subsequently examined. vSub stimulation resulted in plasticity 
      in both the BLA and the NAcc simultaneously. Moreover, depending on stimulus 
      intensity, differential dPAG priming effects on LTP in these two regions were 
      observed. The results demonstrate that negative and positive affect-related 
      processes may be simultaneously modulated. Furthermore, under some conditions 
      lower-level processing areas, such as the dPAG, may differentially modulate 
      plasticity in these regions and thus affect the long-term emotional outcome of 
      the experience.
FAU - Horovitz, Omer
AU  - Horovitz O
AD  - The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa 
      Haifa, Israel.
FAU - Richter-Levin, Gal
AU  - Richter-Levin G
AD  - The Institute for the Study of Affective Neuroscience (ISAN), University of Haifa 
      Haifa, Israel ; Department of Psychology, University of Haifa Haifa, Israel ; 
      Sagol Department of Neurobiology, University of Haifa Haifa, Israel.
LA  - eng
PT  - Journal Article
DEP - 20150304
PL  - Switzerland
TA  - Front Behav Neurosci
JT  - Frontiers in behavioral neuroscience
JID - 101477952
PMC - PMC4349162
OTO - NOTNLM
OT  - BLA
OT  - NAcc
OT  - affect
OT  - dPAG
OT  - modulation
OT  - plasticity
EDAT- 2015/03/20 06:00
MHDA- 2015/03/20 06:01
PMCR- 2015/01/01
CRDT- 2015/03/20 06:00
PHST- 2014/12/25 00:00 [received]
PHST- 2015/02/12 00:00 [accepted]
PHST- 2015/03/20 06:00 [entrez]
PHST- 2015/03/20 06:00 [pubmed]
PHST- 2015/03/20 06:01 [medline]
PHST- 2015/01/01 00:00 [pmc-release]
AID - 10.3389/fnbeh.2015.00053 [doi]
PST - epublish
SO  - Front Behav Neurosci. 2015 Mar 4;9:53. doi: 10.3389/fnbeh.2015.00053. eCollection 
      2015.