PMID- 25789271
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20150319
LR  - 20220318
IS  - 2277-9175 (Print)
IS  - 2277-9175 (Electronic)
IS  - 2277-9175 (Linking)
VI  - 4
DP  - 2015
TI  - Significance of a common variant in the CDKAL1 gene with susceptibility to type 2 
      diabetes mellitus in Iranian population.
PG  - 45
LID - 10.4103/2277-9175.151256 [doi]
LID - 45
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) is a worldwide problem that threatens 
      the public health and economies of all countries. A multifactorial etiology and 
      interaction between environmental factors and genetic components are responsible 
      for triggering and progression of T2DM. Recently, rs7754840 single nucleotide 
      polymorphism (SNP) in the CDKAL1 gene was reported to be associated with T2DM in 
      various populations. However, due to inconsistent results in various populations 
      about the association of rs7754840 with T2DM, and lack of information in the 
      Iranian population, we have evaluated its association with T2DM in a subset of 
      the Iranian population from Isfahan province, central part of Iran. MATERIALS AND 
      METHODS: The study included 140 patients and 140 controls selected based on the 
      World Health Organization guidelines. Genomic DNA was extracted from blood 
      samples and the rs7754840 SNP was genotyped using a polymerase chain 
      reaction-restriction fragment length polymorphism assay with specific primers and 
      restriction enzyme (Ac1I). RESULTS: The frequency of the C allele in the cases 
      was higher than that in the controls (72.9% vs. 65%; P = 0.045). Using logistic 
      regression analysis, we found a significant risk association of CC genotype with 
      T2DM susceptibility (OR = 2.319, 95% CI = 1.436-3.744, P = 0.001). Furthermore, 
      compared with the CC genotype, individuals with the GC genotype had a lower risk 
      (protective association) of developing T2DM (OR = 0.332, 95% CI = 0.202-0.547, P 
      < 0.001). CONCLUSIONS: We confirmed that there is a significant risk association 
      between rs7754840 polymorphism and development of T2DM in a subset of the Iranian 
      population from Isfahan province.
FAU - Mansoori, Yaser
AU  - Mansoori Y
AD  - Department of Biochemistry, School of Medicine, Fasa University of Medical 
      Sciences, Fasa, Iran.
FAU - Daraei, Abdolreza
AU  - Daraei A
AD  - Department of Medical Genetics, School of Medicine, Tehran University of Medical 
      Sciences, Tehran, Iran.
FAU - Naghizadeh, Mohammad Mehdi
AU  - Naghizadeh MM
AD  - Department of Biochemistry, School of Medicine, Fasa University of Medical 
      Sciences, Fasa, Iran.
FAU - Salehi, Rasoul
AU  - Salehi R
AD  - Department of Genetics and Molecular Biology, School of Medicine, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
DEP - 20150211
PL  - India
TA  - Adv Biomed Res
JT  - Advanced biomedical research
JID - 101586897
PMC - PMC4358034
OTO - NOTNLM
OT  - CDKAL1 gene
OT  - single nucleotide polymorphism
OT  - type 2 diabetes mellitus
COIS- Conflict of Interest: None declared.
EDAT- 2015/03/20 06:00
MHDA- 2015/03/20 06:01
PMCR- 2015/02/11
CRDT- 2015/03/20 06:00
PHST- 2014/01/29 00:00 [received]
PHST- 2014/06/23 00:00 [accepted]
PHST- 2015/03/20 06:00 [entrez]
PHST- 2015/03/20 06:00 [pubmed]
PHST- 2015/03/20 06:01 [medline]
PHST- 2015/02/11 00:00 [pmc-release]
AID - ABR-4-45 [pii]
AID - 10.4103/2277-9175.151256 [doi]
PST - epublish
SO  - Adv Biomed Res. 2015 Feb 11;4:45. doi: 10.4103/2277-9175.151256. eCollection 
      2015.