PMID- 25789320
OWN - NLM
STAT- MEDLINE
DCOM- 20151125
LR  - 20220408
IS  - 2314-6141 (Electronic)
IS  - 2314-6133 (Print)
VI  - 2015
DP  - 2015
TI  - Alpha-linolenic acid: an omega-3 fatty acid with neuroprotective properties-ready 
      for use in the stroke clinic?
PG  - 519830
LID - 10.1155/2015/519830 [doi]
LID - 519830
AB  - Alpha-linolenic acid (ALA) is plant-based essential omega-3 polyunsaturated fatty 
      acids that must be obtained through the diet. This could explain in part why the 
      severe deficiency in omega-3 intake pointed by numerous epidemiologic studies may 
      increase the brain's vulnerability representing an important risk factor in the 
      development and/or deterioration of certain cardio- and neuropathologies. The 
      roles of ALA in neurological disorders remain unclear, especially in stroke that 
      is a leading cause of death. We and others have identified ALA as a potential 
      nutraceutical to protect the brain from stroke, characterized by its pleiotropic 
      effects in neuroprotection, vasodilation of brain arteries, and neuroplasticity. 
      This review highlights how chronic administration of ALA protects against rodent 
      models of hypoxic-ischemic injury and exerts an anti-depressant-like activity, 
      effects that likely involve multiple mechanisms in brain, and may be applied in 
      stroke prevention. One major effect may be through an increase in mature 
      brain-derived neurotrophic factor (BDNF), a widely expressed protein in brain 
      that plays critical roles in neuronal maintenance, and learning and memory. 
      Understanding the precise roles of ALA in neurological disorders will provide the 
      underpinnings for the development of new therapies for patients and families who 
      could be devastated by these disorders.
FAU - Blondeau, Nicolas
AU  - Blondeau N
AD  - Institut de Pharmacologie Moleculaire et Cellulaire, Universite de Nice Sophia 
      Antipolis, 660 route des Lucioles, Valbonne, 06560 Sophia Antipolis, France ; 
      CNRS, IPMC, 06560 Sophia Antipolis, France.
FAU - Lipsky, Robert H
AU  - Lipsky RH
AD  - Inova Neuroscience Institute, Inova Health System, Falls Church, VA 22042, USA.
FAU - Bourourou, Miled
AU  - Bourourou M
AD  - Institut de Pharmacologie Moleculaire et Cellulaire, Universite de Nice Sophia 
      Antipolis, 660 route des Lucioles, Valbonne, 06560 Sophia Antipolis, France ; 
      CNRS, IPMC, 06560 Sophia Antipolis, France.
FAU - Duncan, Mark W
AU  - Duncan MW
AD  - Division of Endocrinology, Diabetes & Metabolism, Department of Medicine, School 
      of Medicine, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO 
      80045, USA ; Obesity Research Center, College of Medicine, King Saud University, 
      Riyadh 11461, Saudi Arabia.
FAU - Gorelick, Philip B
AU  - Gorelick PB
AD  - Mercy Health Hauenstein Neurosciences & Department of Translational Science and 
      Molecular Medicine, Michigan State University College of Human Medicine, Grand 
      Rapids, MI, USA.
FAU - Marini, Ann M
AU  - Marini AM
AD  - Department of Neurology and Program in Neuroscience, Uniformed Services 
      University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, 
      USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150219
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 0 (Neuroprotective Agents)
RN  - 0RBV727H71 (alpha-Linolenic Acid)
SB  - IM
MH  - Animals
MH  - Brain/metabolism
MH  - Brain-Derived Neurotrophic Factor/metabolism
MH  - Fatty Acids, Omega-3/*metabolism
MH  - Humans
MH  - Neuroprotective Agents/*metabolism
MH  - Stroke/metabolism/*prevention & control
MH  - alpha-Linolenic Acid/*metabolism
PMC - PMC4350958
EDAT- 2015/03/20 06:00
MHDA- 2015/12/15 06:00
PMCR- 2015/02/19
CRDT- 2015/03/20 06:00
PHST- 2014/04/16 00:00 [received]
PHST- 2014/09/08 00:00 [accepted]
PHST- 2015/03/20 06:00 [entrez]
PHST- 2015/03/20 06:00 [pubmed]
PHST- 2015/12/15 06:00 [medline]
PHST- 2015/02/19 00:00 [pmc-release]
AID - 10.1155/2015/519830 [doi]
PST - ppublish
SO  - Biomed Res Int. 2015;2015:519830. doi: 10.1155/2015/519830. Epub 2015 Feb 19.