PMID- 25789844
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20221207
IS  - 1557-8518 (Electronic)
IS  - 1540-4196 (Linking)
VI  - 13
IP  - 5
DP  - 2015 Jun
TI  - Association between worse metabolic control and increased thyroid volume and 
      nodular disease in elderly adults with metabolic syndrome.
PG  - 221-6
LID - 10.1089/met.2014.0158 [doi]
AB  - BACKGROUND: Metabolic syndrome has been associated with nodular goiter. Our aim 
      was to evaluate which metabolic parameters in elderly patients with metabolic 
      syndrome are associated with thyroid enlargement or increased prevalence of 
      thyroid nodules. METHODS: In this cross-sectional study, 77 patients >65 years of 
      age with metabolic syndrome were included. We evaluated the presence of thyroid 
      nodules and thyroid volume by ultrasonography and several biochemical, metabolic 
      and anthropometric parameters. Only patients with thyrotropin 
      (thyroid-stimulating hormone, TSH) levels between 0.3 and 6 mU/L were included. 
      We further divided subjects into two groups-type 2 diabetes mellitus (T2DM) and 
      non-T2DM and established comparisons between them. RESULTS: Among all parameters 
      analyzed we found a significant correlation between glycated hemoglobin (HbA1c) 
      and volume (r=0.261, P=0.027) or number of nodules (r=0.266, P=0.023). Neither 
      sex, age, body mass index (BMI), metformin, nor levothyroxine use were associated 
      with thyroid volume or nodularity. Within the whole cohort, those patients with 
      T2DM had larger thyroid volumes compared to non-T2DM [median (confidence 
      interval, CI) 6.976 (5.220-10.789) vs. 5.034 (3.796-6.034) mL, P<0.008). 
      Furthermore, a larger proportion of T2DM patients presented thyroid volumes >5.8 
      mL [69 vs. 23%, P<0.001; odds ratio=7.25 (CI 2.04-25.56)]. CONCLUSIONS: In 
      elderly patients with metabolic syndrome, worse metabolic control, represented by 
      higher HbA1c levels, was found associated to increased prevalence of thyroid 
      nodules and larger thyroid volume. Moreover, within the whole metabolic syndrome 
      group, patients with T2DM had the largest thyroid volumes.
FAU - Blanc, Evelyn
AU  - Blanc E
AD  - 1 Department of Endocrinology and Metabolism, Cesar Milstein Hospital , Buenos 
      Aires, Argentina .
FAU - Ponce, Cecilia
AU  - Ponce C
FAU - Brodschi, Dafne
AU  - Brodschi D
FAU - Nepote, Alejandra
AU  - Nepote A
FAU - Barreto, Adriana
AU  - Barreto A
FAU - Schnitman, Marta
AU  - Schnitman M
FAU - Fossati, Pia
AU  - Fossati P
FAU - Salgado, Pablo
AU  - Salgado P
FAU - Cejas, Claudia
AU  - Cejas C
FAU - Faingold, Cristina
AU  - Faingold C
FAU - Musso, Carla
AU  - Musso C
FAU - Brenta, Gabriela
AU  - Brenta G
LA  - eng
PT  - Journal Article
DEP - 20150319
PL  - United States
TA  - Metab Syndr Relat Disord
JT  - Metabolic syndrome and related disorders
JID - 101150318
RN  - 0 (Glycated Hemoglobin A)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (hemoglobin A1c protein, human)
RN  - 9002-71-5 (Thyrotropin)
RN  - 9100L32L2N (Metformin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Anthropometry
MH  - Argentina
MH  - Body Mass Index
MH  - Cohort Studies
MH  - Cross-Sectional Studies
MH  - Diabetes Complications/blood
MH  - Diabetes Mellitus, Type 2/blood
MH  - Female
MH  - Glycated Hemoglobin/chemistry
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Male
MH  - Metabolic Syndrome/complications/*physiopathology
MH  - Metformin/therapeutic use
MH  - Prospective Studies
MH  - Thyroid Diseases/*complications
MH  - Thyroid Gland/*physiology
MH  - Thyroid Nodule/*complications/diagnostic imaging/metabolism
MH  - Thyrotropin/blood
MH  - Thyroxine/therapeutic use
MH  - Ultrasonography
EDAT- 2015/03/20 06:00
MHDA- 2016/03/08 06:00
CRDT- 2015/03/20 06:00
PHST- 2015/03/20 06:00 [entrez]
PHST- 2015/03/20 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
AID - 10.1089/met.2014.0158 [doi]
PST - ppublish
SO  - Metab Syndr Relat Disord. 2015 Jun;13(5):221-6. doi: 10.1089/met.2014.0158. Epub 
      2015 Mar 19.