PMID- 25791070
OWN - NLM
STAT- MEDLINE
DCOM- 20160412
LR  - 20181202
IS  - 1477-2566 (Electronic)
IS  - 1465-3249 (Linking)
VI  - 17
IP  - 7
DP  - 2015 Jul
TI  - Human allogeneic AB0/Rh-identical umbilical cord blood cells in the treatment of 
      juvenile patients with cerebral palsy.
PG  - 969-78
LID - S1465-3249(15)00074-2 [pii]
LID - 10.1016/j.jcyt.2015.02.010 [doi]
AB  - BACKGROUND AIMS: The term "cerebral palsy" (CP) encompasses many syndromes that 
      emerge from brain damage at early stages of ontogenesis and manifest as the 
      inability to retain a normal body position or perform controlled movements. 
      Existing methods of CP treatment, including various rehabilitation strategies and 
      surgical and pharmacological interventions, are mostly palliative, and there is 
      no specific therapy focused on restoring injured brain function. METHODS: During 
      a post-registration clinical investigation, the safety and efficacy of 
      intravenous infusion of allogeneic human leukocyte antigen (HLA)-unmatched 
      umbilical cord blood (UCB) cells were studied in 80 pediatric patients with 
      cerebral palsy and associated neurological complications. Patients received up to 
      6 intravenous infusions of AB0/Rh-identical, red blood cell-depleted UCB cells at 
      an average dose of 250 x 10(6) viable cells per infusion. RESULTS: Patients were 
      followed for 3-36 months, and multiple cell infusions did not cause any adverse 
      effects. In contrast, in most patients who received four or more UCB cell 
      infusions, positive dynamics related to significant improvements in neurological 
      status and/or cognitive functions were observed. CONCLUSIONS: The results confirm 
      that multiple intravenous infusions of allogeneic AB0/Rh-identical UCB cells may 
      be a safe and effective procedure and could be included in treatment and 
      rehabilitation programs for juvenile patients with cerebral palsy.
CI  - Copyright (c) 2015 International Society for Cellular Therapy. Published by 
      Elsevier Inc. All rights reserved.
FAU - Romanov, Yury A
AU  - Romanov YA
AD  - Laboratory of Human Stem Cells, National Cardiology Research Center, Moscow, 
      Russian Federation. Electronic address: romanov@cardio.ru.
FAU - Tarakanov, Oleg P
AU  - Tarakanov OP
AD  - Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
FAU - Radaev, Sergey M
AU  - Radaev SM
AD  - Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
FAU - Dugina, Tamara N
AU  - Dugina TN
AD  - Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
FAU - Ryaskina, Svetlana S
AU  - Ryaskina SS
AD  - Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
FAU - Darevskaya, Anna N
AU  - Darevskaya AN
AD  - Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
FAU - Morozova, Yana V
AU  - Morozova YV
AD  - Cord Blood Bank "CryoCenter", Moscow, Russian Federation.
FAU - Khachatryan, William A
AU  - Khachatryan WA
AD  - Polenov Institute of Neurosurgery, Saint-Petersburg, Russian Federation.
FAU - Lebedev, Konstantin E
AU  - Lebedev KE
AD  - Polenov Institute of Neurosurgery, Saint-Petersburg, Russian Federation.
FAU - Zotova, Nelli S
AU  - Zotova NS
AD  - Kulakov Federal Center of Obstetrics, Gynecology and Perinatology, Moscow, 
      Russian Federation.
FAU - Burkova, Anna S
AU  - Burkova AS
AD  - Kulakov Federal Center of Obstetrics, Gynecology and Perinatology, Moscow, 
      Russian Federation.
FAU - Sukhikh, Gennady T
AU  - Sukhikh GT
AD  - Kulakov Federal Center of Obstetrics, Gynecology and Perinatology, Moscow, 
      Russian Federation.
FAU - Smirnov, Vladimir N
AU  - Smirnov VN
AD  - Laboratory of Human Stem Cells, National Cardiology Research Center, Moscow, 
      Russian Federation.
LA  - eng
PT  - Journal Article
DEP - 20150317
PL  - England
TA  - Cytotherapy
JT  - Cytotherapy
JID - 100895309
RN  - 0 (ABO Blood-Group System)
RN  - 0 (HLA Antigens)
RN  - 0 (Rh-Hr Blood-Group System)
SB  - IM
MH  - ABO Blood-Group System/immunology
MH  - Cell- and Tissue-Based Therapy/*methods
MH  - Cerebral Palsy/*therapy
MH  - Child
MH  - Child, Preschool
MH  - Cord Blood Stem Cell Transplantation/*methods
MH  - Female
MH  - Fetal Blood/*transplantation
MH  - HLA Antigens/immunology
MH  - Humans
MH  - Infant
MH  - Infusions, Intravenous
MH  - Male
MH  - Rh-Hr Blood-Group System/immunology
MH  - Transplantation, Homologous
OTO - NOTNLM
OT  - brain injury
OT  - cell therapy
OT  - cerebral palsy
OT  - umbilical cord blood
EDAT- 2015/03/21 06:00
MHDA- 2016/04/14 06:00
CRDT- 2015/03/21 06:00
PHST- 2014/12/08 00:00 [received]
PHST- 2015/01/26 00:00 [revised]
PHST- 2015/02/09 00:00 [accepted]
PHST- 2015/03/21 06:00 [entrez]
PHST- 2015/03/21 06:00 [pubmed]
PHST- 2016/04/14 06:00 [medline]
AID - S1465-3249(15)00074-2 [pii]
AID - 10.1016/j.jcyt.2015.02.010 [doi]
PST - ppublish
SO  - Cytotherapy. 2015 Jul;17(7):969-78. doi: 10.1016/j.jcyt.2015.02.010. Epub 2015 
      Mar 17.