PMID- 25791538
OWN - NLM
STAT- MEDLINE
DCOM- 20160314
LR  - 20180816
IS  - 1423-0194 (Electronic)
IS  - 0028-3835 (Linking)
VI  - 101
IP  - 3
DP  - 2015
TI  - Diurnal Variation of Plasma Brain-Derived Neurotrophic Factor Levels in Women 
      with Functional Hypothalamic Amenorrhea.
PG  - 256-62
LID - 10.1159/000381456 [doi]
AB  - BACKGROUND: Brain-derived neurotrophic factor (BDNF) is strongly related to 
      hormonal networks and is modulated by hypothalamic activity. OBJECTIVE: To 
      evaluate plasma BDNF concentration in patients with functional hypothalamic 
      amenorrhea (FHA), with reference to the BDNF circadian rhythm and its relation 
      with the cortisol (F) rhythm, and to assess whether the duration of amenorrhea 
      might influence the BDNF:F ratio in FHA. DESIGN: This was an observational study 
      evaluating 36 amenorrheic and 30 eumenorrheic women. SETTING: Basal values of 
      BDNF and hormones were examined in blood samples collected from 7:00 to 9:00 h in 
      all the women. Basal BDNF and F levels were determined in blood samples collected 
      in 12 subjects from each group at 8:00, 12:00, 16:00, 20:00, and 24:00 h. 
      RESULTS: BDNF plasma levels are significantly lower in amenorrheic women (p < 
      0.001) than in the follicular phase of eumenorrheic women. There are no 
      correlations between BDNF values (p > 0.05), sex steroids, and F in FHA. Low 
      plasma BDNF levels in FHA are not significantly correlated with duration of 
      amenorrhea. The 24-hour variation of BDNF in amenorrheic women is significantly 
      lower when compared to the control group, and normal daily variations of BDNF 
      disappeared in FHA patients. F preserved its circadian rhythm in both groups. 
      CONCLUSIONS: Interactions between BDNF, the hypothalamus-pituitary-adrenal axis, 
      and sex steroids might be critical in clinical conditions of modified 
      homeostasis/adaptation, such as FHA.
CI  - (c) 2015 S. Karger AG, Basel.
FAU - Drakopoulos, Panagiotis
AU  - Drakopoulos P
AD  - Division of Gynecology and Obstetrics, University Hospital of Geneva, Geneva, 
      Switzerland.
FAU - Casarosa, Elena
AU  - Casarosa E
FAU - Bucci, Fiorella
AU  - Bucci F
FAU - Piccinino, Manuela
AU  - Piccinino M
FAU - Wenger, Jean-Marie
AU  - Wenger JM
FAU - Nappi, Rossella Elena
AU  - Nappi RE
FAU - Polyzos, Nicholas
AU  - Polyzos N
FAU - Genazzani, Andrea Riccardo
AU  - Genazzani AR
FAU - Pluchino, Nicola
AU  - Pluchino N
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20150313
PL  - Switzerland
TA  - Neuroendocrinology
JT  - Neuroendocrinology
JID - 0035665
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adult
MH  - Amenorrhea/*blood
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - *Circadian Rhythm
MH  - Female
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Hypothalamo-Hypophyseal System/*metabolism/physiopathology
MH  - Pituitary-Adrenal System/*metabolism/physiopathology
MH  - Young Adult
EDAT- 2015/03/21 06:00
MHDA- 2016/03/15 06:00
CRDT- 2015/03/21 06:00
PHST- 2014/10/06 00:00 [received]
PHST- 2015/03/07 00:00 [accepted]
PHST- 2015/03/21 06:00 [entrez]
PHST- 2015/03/21 06:00 [pubmed]
PHST- 2016/03/15 06:00 [medline]
AID - 000381456 [pii]
AID - 10.1159/000381456 [doi]
PST - ppublish
SO  - Neuroendocrinology. 2015;101(3):256-62. doi: 10.1159/000381456. Epub 2015 Mar 13.