PMID- 25791734
OWN - NLM
STAT- MEDLINE
DCOM- 20150706
LR  - 20181202
IS  - 1745-7262 (Electronic)
IS  - 1008-682X (Print)
IS  - 1008-682X (Linking)
VI  - 17
IP  - 3
DP  - 2015 May-Jun
TI  - How to make a human germ cell.
PG  - 441-2
LID - 10.4103/1008-682X.151401 [doi]
AB  - How the primordial germ cell (PGC) lineage, which eventually gives rise to 
      spermatozoa in males and oocytes in females, is established in the developing 
      mammalian embryo has been a critical topic in both developmental and reproductive 
      biology for many years. There have been significant breakthroughs over the past 
      two decades in establishing both the source of PGCs and the factors that regulate 
      the specification of this lineage in mice, [1] but our understanding of the 
      factors that control PGC development in the human is rudimentary. The SRY-related 
      HMG-box (SOX) family of transcription factors consists of 20 genes in humans and 
      mice that are involved in the maintenance of pluripotency, male sexual 
      development, and other processes. A recent paper in Cell has identified one 
      member of this family, SOX17, as an essential factor for inducing the PGC lineage 
      in humans. [2] Surprisingly, this protein does not appear to have a role in PGC 
      specification in mice. This work not only introduces a new and important player 
      to the field of germ cell specification, but also emphasizes the uniqueness of 
      human PGC development compared to more extensively studied mouse models.
FAU - Cooke, Paul S
AU  - Cooke PS
AD  - Department of Physiological Sciences, College of Veterinary Medicine, University 
      of Florida, Gainesville, FL 32608, USA.
FAU - Nanjappa, Manjunatha K
AU  - Nanjappa MK
LA  - eng
PT  - Comment
PT  - Journal Article
PL  - China
TA  - Asian J Androl
JT  - Asian journal of andrology
JID - 100942132
RN  - 0 (SOXF Transcription Factors)
SB  - IM
CON - Cell. 2015 Jan 15;160(1-2):253-68. PMID: 25543152
MH  - Animals
MH  - *Cell Differentiation
MH  - Germ Cells/*cytology
MH  - Humans
MH  - SOXF Transcription Factors/*metabolism
PMC - PMC4430946
EDAT- 2015/03/21 06:00
MHDA- 2015/07/07 06:00
PMCR- 2015/05/01
CRDT- 2015/03/21 06:00
PHST- 2015/03/21 06:00 [entrez]
PHST- 2015/03/21 06:00 [pubmed]
PHST- 2015/07/07 06:00 [medline]
PHST- 2015/05/01 00:00 [pmc-release]
AID - 151401 [pii]
AID - AJA-17-441 [pii]
AID - 10.4103/1008-682X.151401 [doi]
PST - ppublish
SO  - Asian J Androl. 2015 May-Jun;17(3):441-2. doi: 10.4103/1008-682X.151401.