PMID- 25793750
OWN - NLM
STAT- MEDLINE
DCOM- 20171211
LR  - 20171222
IS  - 1563-5244 (Electronic)
IS  - 0883-0185 (Linking)
VI  - 35
IP  - 5
DP  - 2016 Sep 2
TI  - Distinct Strategies Employed by Dendritic Cells and Macrophages in Restricting 
      Mycobacterium tuberculosis Infection: Different Philosophies but Same Desire.
PG  - 386-398
AB  - Dendritic cells (DCs) and macrophages (Mvarphis) are professional antigen-presenting 
      cells (APCs) that can efficiently phagocytose Mycobacterium tuberculosis (Mtb), 
      the etiological agent of tuberculosis (TB). It is quite interesting to mention 
      here that DCs and Mvarphis use distinct strategies to combat and eliminate Mtb. 
      Similarly, Mtb employs different mechanisms to counteract the action of DCs and 
      Mvarphis. Mvarphis are evolved with specialized, innate, defensive machinery to restrict 
      growth of Mtb at the initial phase of infection. However, DCs are more endowed 
      toward initiating adaptive immunity by activating naive T cells. During encounter 
      with Mtb, DCs and Mvarphis deliver discrete functions via triggering through different 
      pattern recognition receptors (PRRs) expressed by these APCs. Mtb-infected DCs 
      and Mvarphis show differential expression of genes encoding cytokines, chemokines, 
      costimulatory molecules, and adhesion molecules. Interestingly, Mtb impairs the 
      immune defensive machinery by exploiting various PRRs. Remarkably, selective 
      signaling through PRRs by Mtb abrogates the bactericidal activity of Mvarphis, but 
      subverts differentiation of monocytes to DCs. In this article, we highlight the 
      role of PRRs in inducing distinct immune response by DCs and Mvarphis against Mtb. 
      Concurrently, we also discuss smart strategies exploited by Mtb to impair the 
      function of host DCs and Mvarphis.
FAU - Khan, Nargis
AU  - Khan N
AD  - a CSIR-Institute of Microbial Technology , Chandigarh , India.
FAU - Vidyarthi, Aurobind
AU  - Vidyarthi A
AD  - a CSIR-Institute of Microbial Technology , Chandigarh , India.
FAU - Pahari, Susanta
AU  - Pahari S
AD  - a CSIR-Institute of Microbial Technology , Chandigarh , India.
FAU - Agrewala, Javed N
AU  - Agrewala JN
AD  - a CSIR-Institute of Microbial Technology , Chandigarh , India.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150320
PL  - England
TA  - Int Rev Immunol
JT  - International reviews of immunology
JID - 8712260
RN  - 0 (Receptors, Pattern Recognition)
SB  - IM
MH  - Adaptive Immunity
MH  - Animals
MH  - Antigen Presentation
MH  - Bacteriolysis
MH  - Cell Differentiation
MH  - Dendritic Cells/*immunology
MH  - Humans
MH  - Immune Evasion
MH  - Immunity, Innate
MH  - Macrophages/*immunology
MH  - Mycobacterium tuberculosis/*immunology
MH  - Receptors, Pattern Recognition/metabolism
MH  - Tuberculosis/*immunology
OTO - NOTNLM
OT  - Mycobacterium tuberculosis
OT  - chemokines
OT  - cytokines
OT  - dendritic cells
OT  - macrophages
OT  - pattern recognition receptors
EDAT- 2015/03/21 06:00
MHDA- 2017/12/12 06:00
CRDT- 2015/03/21 06:00
PHST- 2015/03/21 06:00 [pubmed]
PHST- 2017/12/12 06:00 [medline]
PHST- 2015/03/21 06:00 [entrez]
AID - 10.3109/08830185.2015.1015718 [doi]
PST - ppublish
SO  - Int Rev Immunol. 2016 Sep 2;35(5):386-398. doi: 10.3109/08830185.2015.1015718. 
      Epub 2015 Mar 20.