PMID- 25794804
OWN - NLM
STAT- MEDLINE
DCOM- 20160107
LR  - 20150420
IS  - 1872-7573 (Electronic)
IS  - 0378-8741 (Linking)
VI  - 166
DP  - 2015 May 26
TI  - Lysimachia christinae Hance regresses preestablished cholesterol gallstone in 
      mice.
PG  - 102-8
LID - S0378-8741(15)00175-0 [pii]
LID - 10.1016/j.jep.2015.03.031 [doi]
AB  - ETHNOPHARMACOLOGICAL RELEVANCE: Whole herb of Lysimachia christinae has long been 
      used as a remedy for cholelithiasis extensively in China. This study was aimed to 
      validate the effect of L. christinae on eliminating preestablished cholesterol 
      gallstone (CGS) in model animals. MATERIALS AND METHODS: Acute toxicity of 
      aqueous extract of L. christinae (LCAE) was estimated in male C57BL/6 mice, so 
      was the efficiency of LCAE on preformed CGS induced by lithogenic diet. The 
      effects of LCAE were also examined on bile secretion rate, the lipid profiles of 
      bile and serum, body weight, main visceral organ indexes, and histomorphology of 
      main visceral organs. RESULTS: Single dose of LCAE did not lead to death and 
      changes on body weight gain, main visceral organ indexes, histomorphology of main 
      visceral organs, and blood hemogram and biochemical indexes, even at dose of 50g 
      material/kg body weight. Preestablished CGSs were almost entirely eliminated 
      after administration of LCAE for 2wk at high dose or for 4wk at low dose. LCAE 
      promoted bile secretion and lowered cholesterol levels in either cystic bile or 
      hepatic bile. LCAE also decreased serum cholesterol content, especially LDL-C 
      content, tremendously, reduced the levels of serum HDL-C, phospholipid, and 
      triglycerine a little, and lowered body weight and liver index significantly. 
      After medication of LCAE for 8wk , neither visceral indexes nor histomorphology 
      of heart, kidney, and spleen were influenced, but fatty degeneration of liver 
      induced by high fat and high cholesterol diet was reverted. CONCLUSION: L. 
      christinae can be considered as non-toxic. It showed prominent efficiency of 
      eliminating preexisted CGS in mice and indicated a hypolipidaemic effect.
CI  - Copyright (c) 2015 Elsevier Ireland Ltd. All rights reserved.
FAU - Deng, Jun
AU  - Deng J
AD  - College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, 
      China. Electronic address: dengjcq@163.com.
FAU - Ren, Menglin
AU  - Ren M
AD  - College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, 
      China.
FAU - Dai, Xiaoqiong
AU  - Dai X
AD  - College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, 
      China.
FAU - Qu, Dahai
AU  - Qu D
AD  - College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, 
      China.
FAU - Yang, Maoxia
AU  - Yang M
AD  - College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, 
      China.
FAU - Zhang, Tan
AU  - Zhang T
AD  - College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, 
      China.
FAU - Jiang, Bowen
AU  - Jiang B
AD  - College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20150318
PL  - Ireland
TA  - J Ethnopharmacol
JT  - Journal of ethnopharmacology
JID - 7903310
RN  - 0 (Phospholipids)
RN  - 0 (Plant Extracts)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Animals
MH  - Bile/drug effects
MH  - Body Weight/drug effects
MH  - Cholesterol/*metabolism
MH  - Diet
MH  - Disease Models, Animal
MH  - Gallstones/*drug therapy
MH  - Heart/drug effects
MH  - Kidney/drug effects/metabolism
MH  - Lipid Metabolism/drug effects
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Phospholipids/blood
MH  - Plant Extracts/chemistry/*pharmacology
MH  - Primulaceae/*chemistry
MH  - Spleen/drug effects/metabolism
OTO - NOTNLM
OT  - Cholesterol gallstone
OT  - Lysimachia christinae
OT  - Primulaceae
EDAT- 2015/03/22 06:00
MHDA- 2016/01/08 06:00
CRDT- 2015/03/22 06:00
PHST- 2014/10/16 00:00 [received]
PHST- 2015/01/12 00:00 [revised]
PHST- 2015/03/09 00:00 [accepted]
PHST- 2015/03/22 06:00 [entrez]
PHST- 2015/03/22 06:00 [pubmed]
PHST- 2016/01/08 06:00 [medline]
AID - S0378-8741(15)00175-0 [pii]
AID - 10.1016/j.jep.2015.03.031 [doi]
PST - ppublish
SO  - J Ethnopharmacol. 2015 May 26;166:102-8. doi: 10.1016/j.jep.2015.03.031. Epub 
      2015 Mar 18.