PMID- 25794879
OWN - NLM
STAT- MEDLINE
DCOM- 20161213
LR  - 20220408
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Linking)
VI  - 52
IP  - 5
DP  - 2015 Oct
TI  - Cut-off points of homeostasis model assessment of insulin resistance, beta-cell 
      function, and fasting serum insulin to identify future type 2 diabetes: Tehran 
      Lipid and Glucose Study.
PG  - 905-15
LID - 10.1007/s00592-015-0730-3 [doi]
AB  - AIMS: To determine cut-off points of homeostasis model assessment of insulin 
      resistance (HOMA-IR), beta-cell function (HOMA-B), insulin sensitivity (HOMA-S), and 
      fasting insulin for identifying the subjects with type 2 diabetes mellitus (T2DM) 
      in Iranian adults using data from a prospective population-based study. METHODS: 
      From participants of Tehran Lipid and Glucose Study, 4942 Iranian subjects, aged 
      20-86 years, were followed for incident T2DM. Fasting serum insulin was 
      determined by the electrochemiluminescence immunoasaay. The associations between 
      HOMA-IR, HOMA-B, HOMA-S, and fasting insulin and incident T2DM were evaluated 
      using Cox proportional hazards models. The receiver operator characteristic curve 
      analysis was used to determine the cut-off points of HOMA-IR, HOMA-B, HOMA-S, and 
      fasting insulin. RESULTS: After 9.2 year follow-up, 346 (7.0 %) incident cases of 
      T2DM were identified; the risk-factor-adjusted hazard ratios for HOMA1-IR, 
      HOMA2-IR, HOMA1-B, HOMA2-B, HOMA1-S, HOMA2-S, and insulin were 1.15, 1.70, 0.732, 
      0.997, 0.974, 0.986, and 1.01 in women and 1.37, 1.67, 0.588, 0.993, 0.986, 
      0.991, and 1.06 in men, respectively (all p < 0.05 except for HOMA2-B in women). 
      Optimal cut-off points for HOMA1-IR, HOMA2-IR, HOMA1-B, HOMA2-B, HOMA1-S, 
      HOMA2-S, and insulin were 1.85, 1.41, 86.2, 72.5, 54.1, 63.7, and 11.13 microU/ml in 
      women and 2.17, 1.18, 67.1, 74.6, 46.1, 74.1, and 9.16 microU/ml in men, 
      respectively. CONCLUSIONS: HOMA-IR, HOMA-B (except for HOMA2-B in women), HOMA-S, 
      and fasting insulin were independent predictors of T2DM. Optimal cut-off points 
      of HOMA-IR, HOMA-B, HOMA-S, and fasting serum insulin were determined from a 
      population-based study for identifying incident T2DM.
FAU - Ghasemi, Asghar
AU  - Ghasemi A
AD  - Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Tohidi, Maryam
AU  - Tohidi M
AD  - Prevention of Metabolic Disorder Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, 
      Parvaneh Street, Velenjak, P.O. Box 19395-4763, Tehran, Iran. 
      Tohidi@endocrine.ac.ir.
FAU - Derakhshan, Arash
AU  - Derakhshan A
AD  - Prevention of Metabolic Disorder Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, 
      Parvaneh Street, Velenjak, P.O. Box 19395-4763, Tehran, Iran.
FAU - Hasheminia, Mitra
AU  - Hasheminia M
AD  - Prevention of Metabolic Disorder Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, 
      Parvaneh Street, Velenjak, P.O. Box 19395-4763, Tehran, Iran.
FAU - Azizi, Fereidoun
AU  - Azizi F
AD  - Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Hadaegh, Farzad
AU  - Hadaegh F
AD  - Prevention of Metabolic Disorder Research Center, Research Institute for 
      Endocrine Sciences, Shahid Beheshti University of Medical Sciences, No. 24, 
      Parvaneh Street, Velenjak, P.O. Box 19395-4763, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150322
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 0 (Lipids)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Anthropometry
MH  - Blood Glucose/analysis
MH  - Diabetes Mellitus, Type 2/blood/*diagnosis
MH  - Female
MH  - Follow-Up Studies
MH  - *Homeostasis
MH  - Humans
MH  - Insulin/*blood
MH  - *Insulin Resistance
MH  - *Insulin-Secreting Cells
MH  - Iran
MH  - Lipids/blood
MH  - Male
MH  - Middle Aged
MH  - Models, Biological
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - Reference Values
MH  - Young Adult
OTO - NOTNLM
OT  - Cut-off points
OT  - Epidemiology
OT  - HOMA-B
OT  - HOMA-IR
OT  - HOMA-S
OT  - Insulin resistance
OT  - Type 2 diabetes
EDAT- 2015/03/22 06:00
MHDA- 2016/12/15 06:00
CRDT- 2015/03/22 06:00
PHST- 2014/12/16 00:00 [received]
PHST- 2015/02/26 00:00 [accepted]
PHST- 2015/03/22 06:00 [entrez]
PHST- 2015/03/22 06:00 [pubmed]
PHST- 2016/12/15 06:00 [medline]
AID - 10.1007/s00592-015-0730-3 [pii]
AID - 10.1007/s00592-015-0730-3 [doi]
PST - ppublish
SO  - Acta Diabetol. 2015 Oct;52(5):905-15. doi: 10.1007/s00592-015-0730-3. Epub 2015 
      Mar 22.