PMID- 25794986
OWN - NLM
STAT- MEDLINE
DCOM- 20151112
LR  - 20181113
IS  - 1435-702X (Electronic)
IS  - 0721-832X (Linking)
VI  - 253
IP  - 6
DP  - 2015 Jun
TI  - Correlation between depth and area of retinal nerve fiber layer defect as 
      measured by spectral domain optical coherence tomography.
PG  - 925-34
LID - 10.1007/s00417-015-2982-6 [doi]
AB  - BACKGROUND: To evaluate the correlation between the depth and area of retinal 
      nerve fiber layer (RNFL) defect, as measured on an RNFL map of spectral-domain 
      optical coherence tomography (SD-OCT). METHODS: The RNFL of 472 glaucoma subjects 
      and of 217 healthy subjects was imaged by an SD-OCT. RNFL defect depth and area 
      on the RNFL map were expressed as an RNFL defect depth percentage index (RDPI) 
      and an RNFL defect area index (RDAI), respectively, according to the following 
      two formulas: 100x[1-summation of thicknesses of RNFL defects/summation of 
      thicknesses of upper 95th percentile range of age-matched healthy subjects in 
      areas corresponding to defects]; 100x[number of superpixels of RNFL 
      defects/(46 x 46-superpixels inside optic disc or beta zone parapapillary atrophy)]. 
      The best-fitting model describing the relationship between the two parameters was 
      derived by fractional polynomial analysis. RESULTS: Logarithmic fit was 
      determined to be the best-fitting model in describing the relationship of the 
      RDPI against the RDAI (y = 53.4 + 3.7 ln(x) and y = 50.9 + 5.9 ln(x) in superior 
      and inferior hemifields, respectively). The expected RDAIs at the point where the 
      RDPI and RDAI rates of change were the same were 3.7 and 5.9 %; the corresponding 
      upper 95 % confidence interval limits of the RDPI 59.0 and 61.8 % in the superior 
      and inferior hemifields, respectively. CONCLUSIONS: The correlation between the 
      RNFL defect depth and area, as derived from the RNFL map, was best described by 
      the logarithmic fit. Changes were more marked in depth than in area, especially 
      for mild localized defects.
FAU - Suh, Min Hee
AU  - Suh MH
AD  - Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of 
      Medicine, 1435 Jwa-dong, Haeundae-gu, Busan, 612-030, Korea, 
      crishuna0@hanmail.net.
FAU - Yoo, Byeong Wook
AU  - Yoo BW
FAU - Park, Ki Ho
AU  - Park KH
FAU - Kim, Jung Yup
AU  - Kim JY
FAU - Kim, Hyunjoong
AU  - Kim H
FAU - Kim, Hee Chan
AU  - Kim HC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150322
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Aged
MH  - Female
MH  - Glaucoma/*diagnosis
MH  - Gonioscopy
MH  - Humans
MH  - Intraocular Pressure
MH  - Male
MH  - Middle Aged
MH  - Nerve Fibers/*pathology
MH  - Optic Disk/*pathology
MH  - Optic Nerve Diseases/*diagnosis
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence
MH  - Visual Acuity/physiology
MH  - Visual Fields/physiology
EDAT- 2015/03/22 06:00
MHDA- 2015/11/13 06:00
CRDT- 2015/03/22 06:00
PHST- 2014/08/12 00:00 [received]
PHST- 2015/03/02 00:00 [accepted]
PHST- 2015/01/06 00:00 [revised]
PHST- 2015/03/22 06:00 [entrez]
PHST- 2015/03/22 06:00 [pubmed]
PHST- 2015/11/13 06:00 [medline]
AID - 10.1007/s00417-015-2982-6 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 2015 Jun;253(6):925-34. doi: 
      10.1007/s00417-015-2982-6. Epub 2015 Mar 22.