PMID- 25795502
OWN - NLM
STAT- MEDLINE
DCOM- 20151215
LR  - 20220408
IS  - 1558-4488 (Electronic)
IS  - 0270-9295 (Linking)
VI  - 35
IP  - 1
DP  - 2015 Jan
TI  - Sepsis-associated AKI: epithelial cell dysfunction.
PG  - 85-95
LID - S0270-9295(15)00010-8 [pii]
LID - 10.1016/j.semnephrol.2015.01.009 [doi]
AB  - Acute kidney injury (AKI) occurs frequently in critically ill patients with 
      sepsis, in whom it doubles the mortality rate and half of the survivors suffer 
      permanent kidney damage or chronic kidney disease. Failure in the development of 
      viable therapies has prompted studies to better elucidate the cellular and 
      molecular etiologies of AKI, which have generated novel theories and paradigms 
      for the mechanisms of this disease. These studies have shown multifaceted origins 
      and elements of AKI that, in addition to/in lieu of ischemia, include the 
      generation of damage-associated molecular patterns and pathogen-associated 
      molecular patterns, the inflammatory response, humoral and cellular immune 
      activation, perturbation of microvascular flow and oxidative stress, bioenergetic 
      alterations, cell-cycle alterations, and cellular 
      de-differentiation/re-differentiation. It is becoming clear that a major 
      etiologic effector of all these inputs is the renal tubule epithelial cell 
      (RTEC). This review discusses these elements and their effects on RTECs, and 
      reviews the current hypotheses of how these effects may determine the fate of 
      RTECs during sepsis-induced AKI.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Emlet, David R
AU  - Emlet DR
AD  - Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA; 
      Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA.
FAU - Shaw, Andrew D
AU  - Shaw AD
AD  - Department of Anesthesia, Vanderbilt University School of Medicine, Nashville, 
      TN.
FAU - Kellum, John A
AU  - Kellum JA
AD  - Center for Critical Care Nephrology, University of Pittsburgh, Pittsburgh, PA; 
      Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA. 
      Electronic address: kellumja@ccm.upmc.edu.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Semin Nephrol
JT  - Seminars in nephrology
JID - 8110298
SB  - IM
MH  - Acute Kidney Injury/etiology/metabolism/*physiopathology
MH  - Epithelial Cells/*metabolism/physiology
MH  - Humans
MH  - Inflammation
MH  - Kidney/*metabolism/physiopathology
MH  - Kidney Tubules, Distal/cytology
MH  - Kidney Tubules, Proximal/cytology
MH  - Oxidative Stress
MH  - Sepsis/complications/metabolism/*physiopathology
OTO - NOTNLM
OT  - DAMPs and PAMPs
OT  - Sepsis
OT  - acute kidney injury
OT  - renal tubule epithelial cell
EDAT- 2015/03/22 06:00
MHDA- 2015/12/17 06:00
CRDT- 2015/03/22 06:00
PHST- 2015/03/22 06:00 [entrez]
PHST- 2015/03/22 06:00 [pubmed]
PHST- 2015/12/17 06:00 [medline]
AID - S0270-9295(15)00010-8 [pii]
AID - 10.1016/j.semnephrol.2015.01.009 [doi]
PST - ppublish
SO  - Semin Nephrol. 2015 Jan;35(1):85-95. doi: 10.1016/j.semnephrol.2015.01.009.