PMID- 2579588
OWN - NLM
STAT- MEDLINE
DCOM- 19850410
LR  - 20171213
IS  - 0002-9513 (Print)
IS  - 0002-9513 (Linking)
VI  - 248
IP  - 3 Pt 2
DP  - 1985 Mar
TI  - Norepinephrine-induced phasic activity in tail arteries from genetically 
      hypertensive rats.
PG  - H419-23
AB  - The effects of norepinephrine on contractile force development were studied in 
      tail artery strips from spontaneously hypertensive stroke-prone (SHRSP) and 
      Kyoto-Wistar normotensive rats (WKY). The strips were mounted in physiological 
      salt solution between a fixed base and force transducers; isometric contractions 
      were recorded. Norepinephrine-induced were characterized by fluctuations in 
      contractile activity, whereas contractile responses in arteries from WKY remained 
      constant with time. The magnitude and frequency of phasic responses in SHRSP 
      arteries varied directly with increasing concentrations of norepinephrine (1.8 X 
      10(-9) to 1.8 X 10(-6) M). The phasic responses induced by norepinephrine in 
      SHRSP arteries were reversed by the following experimental interventions: 1) 
      10(-4) M ouabain; 2) 20 degrees C; 3) potassium-free solution; 4) 1.0 mM BaCl2; 
      5) 20 mM KCl; 6) 30 mM tetraethylammonium chloride; 7) chloride-free solution; 
      and 8) 10(-7) M D 600 (calcium channel blocker). It is proposed that the phasic 
      contractile responses to norepinephrine in SHRSP are related to altered movements 
      of calcium and potassium across the cell membrane. This study demonstrates a very 
      distinct functional individuality in the arterial vascular smooth muscle cell 
      membrane of SHRSP.
FAU - Myers, J H
AU  - Myers JH
FAU - Lamb, F S
AU  - Lamb FS
FAU - Webb, R C
AU  - Webb RC
LA  - eng
GR  - HL-00813/HL/NHLBI NIH HHS/United States
GR  - HL-18575/HL/NHLBI NIH HHS/United States
GR  - HL-27020/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Am J Physiol
JT  - The American journal of physiology
JID - 0370511
RN  - 0 (Calcium Channel Blockers)
RN  - 0 (Ion Channels)
RN  - 0 (Tetraethylammonium Compounds)
RN  - 5ACL011P69 (Ouabain)
RN  - 66-40-0 (Tetraethylammonium)
RN  - RWP5GA015D (Potassium)
RN  - SY7Q814VUP (Calcium)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Animals
MH  - Arteries/physiopathology
MH  - Blood Pressure
MH  - Calcium/metabolism
MH  - Calcium Channel Blockers/pharmacology
MH  - Cell Membrane Permeability
MH  - Hypertension/genetics/metabolism/*physiopathology
MH  - Ion Channels/drug effects/metabolism
MH  - Male
MH  - Muscle Contraction
MH  - Muscle, Smooth, Vascular/*drug effects/metabolism
MH  - Norepinephrine/*pharmacology
MH  - Ouabain/pharmacology
MH  - Potassium/metabolism
MH  - Rats
MH  - Rats, Inbred SHR
MH  - Rats, Inbred WKY
MH  - Tail/blood supply
MH  - Tetraethylammonium
MH  - Tetraethylammonium Compounds/pharmacology
EDAT- 1985/03/01 00:00
MHDA- 1985/03/01 00:01
CRDT- 1985/03/01 00:00
PHST- 1985/03/01 00:00 [pubmed]
PHST- 1985/03/01 00:01 [medline]
PHST- 1985/03/01 00:00 [entrez]
AID - 10.1152/ajpheart.1985.248.3.H419 [doi]
PST - ppublish
SO  - Am J Physiol. 1985 Mar;248(3 Pt 2):H419-23. doi: 
      10.1152/ajpheart.1985.248.3.H419.