PMID- 25796216
OWN - NLM
STAT- MEDLINE
DCOM- 20151008
LR  - 20181202
IS  - 1573-2622 (Electronic)
IS  - 0012-4486 (Print)
IS  - 0012-4486 (Linking)
VI  - 131
IP  - 1
DP  - 2015 Aug
TI  - Rapid resolution of retinoschisis with acetazolamide.
PG  - 63-70
LID - 10.1007/s10633-015-9496-8 [doi]
AB  - PURPOSE: To report the results of an acetazolamide (Diamox((R))) treatment regimen 
      in a genetically confirmed case of X-linked juvenile retinoschisis (XLRS). 
      METHODS: A patient with XLRS was prescribed acetazolamide (Diamox((R))) at a dose 
      of 500 mg/day, then discontinued the treatment due to non-compliance for 4 days, 
      and finally resumed the course of treatment. Best-corrected visual acuity, 
      retinal structure, and function were monitored with autofluorescence, spectral 
      domain-optical coherence tomography (SD-OCT), adaptive optics scanning laser 
      ophthalmoscopy (AOSLO), and full-field electroretinogram (ERG). Full-field ERG 
      was performed using DTL recording electrodes and Ganzfeld stimulation according 
      to ISCEV standards. RESULTS: Serial monitoring of the cysts by SD-OCT revealed a 
      strong association between the effects of acetazolamide administration and the 
      size of the schisis. A reduction in foveal cyst size was significant in as rapid 
      as 6 days after acetazolamide initiation. AOSLO data revealed that the resolution 
      of cone cell images improves as the foveal schisis decreases in size. 
      CONCLUSIONS: Efficacy of acetazolamide in patients with XLRS can be apparent in 
      as rapid as a week of therapy. AOSLO can be a good method to evaluate the cone 
      cells after acetazolamide treatment in the early stages of XLRS.
FAU - Zhang, Lijuan
AU  - Zhang L
AD  - Barbara and Donald Jonas Laboratory of Stem Cell and Regenerative Medicine, 
      Department of Ophthalmology, Columbia University, New York, NY, USA.
FAU - Reyes, Roberto
AU  - Reyes R
FAU - Lee, Winston
AU  - Lee W
FAU - Chen, Ching-Lung
AU  - Chen CL
FAU - Chan, Lawrence
AU  - Chan L
FAU - Sujirakul, Tharikarn
AU  - Sujirakul T
FAU - Chang, Stanley
AU  - Chang S
FAU - Tsang, Stephen H
AU  - Tsang SH
LA  - eng
GR  - R01EY018213/EY/NEI NIH HHS/United States
GR  - R01 EY018213/EY/NEI NIH HHS/United States
GR  - T34 GM008718/GM/NIGMS NIH HHS/United States
GR  - P30EY019007/EY/NEI NIH HHS/United States
GR  - P30 EY019007/EY/NEI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
DEP - 20150322
PL  - Netherlands
TA  - Doc Ophthalmol
JT  - Documenta ophthalmologica. Advances in ophthalmology
JID - 0370667
RN  - 0 (Carbonic Anhydrase Inhibitors)
RN  - O3FX965V0I (Acetazolamide)
SB  - IM
MH  - Acetazolamide/*therapeutic use
MH  - Carbonic Anhydrase Inhibitors/*therapeutic use
MH  - Electroretinography
MH  - Humans
MH  - Male
MH  - Ophthalmoscopy
MH  - Retina/physiopathology
MH  - Retinoschisis/*drug therapy/physiopathology
MH  - Tomography, Optical Coherence/methods
MH  - Visual Acuity/physiology
MH  - Young Adult
PMC - PMC4504776
MID - NIHMS674576
COIS- Disclosures: The authors report no conflicts of interest in this work
EDAT- 2015/03/23 06:00
MHDA- 2015/10/09 06:00
PMCR- 2016/08/01
CRDT- 2015/03/23 06:00
PHST- 2014/07/24 00:00 [received]
PHST- 2015/03/16 00:00 [accepted]
PHST- 2015/03/23 06:00 [entrez]
PHST- 2015/03/23 06:00 [pubmed]
PHST- 2015/10/09 06:00 [medline]
PHST- 2016/08/01 00:00 [pmc-release]
AID - 10.1007/s10633-015-9496-8 [doi]
PST - ppublish
SO  - Doc Ophthalmol. 2015 Aug;131(1):63-70. doi: 10.1007/s10633-015-9496-8. Epub 2015 
      Mar 22.