PMID- 25796450
OWN - NLM
STAT- MEDLINE
DCOM- 20160204
LR  - 20150518
IS  - 1879-0003 (Electronic)
IS  - 0141-8130 (Linking)
VI  - 77
DP  - 2015
TI  - Interaction of three new tetradentates Schiff bases containing N2O2 donor atoms 
      with calf thymus DNA.
PG  - 193-202
LID - S0141-8130(15)00167-1 [pii]
LID - 10.1016/j.ijbiomac.2015.03.016 [doi]
AB  - Interaction of 1,3-bis(2-hydroxy-benzylidene)-urea (H2L1), 
      1,3-bis(2-hydroxy-3-methoxy-benzylidene)-urea (H2L2) and 
      1,3-bis(2-hydroxy-3-methoxy-benzylidene)-urea nickel(II) (NiL2) with calf-thymus 
      DNA were investigated by UV-vis absorption, fluorescence emission and circular 
      dichroism (CD) spectroscopy as well as cyclic voltammetry, viscosity 
      measurements, molecular docking and molecular dynamics simulation. Binding 
      constants were determined using UV-vis absorption and fluorescence spectra. The 
      results indicated that studied Schiff-bases bind to DNA in the intercalative mode 
      in which the metal derivative is more effective than non metals. Their 
      interaction trend is further determined by molecular dynamics (MD) simulation. MD 
      results showed that Ni derivative reduces oligonucleotide intermolecular hydrogen 
      bond and increases solvent accessible surface area more than other compounds.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Ajloo, Davood
AU  - Ajloo D
AD  - School of Chemistry, Damghan University, Damghan, Iran. Electronic address: 
      ajloo@du.ac.ir.
FAU - Shabanpanah, Sajede
AU  - Shabanpanah S
AD  - School of Chemistry, Damghan University, Damghan, Iran.
FAU - Shafaatian, Bita
AU  - Shafaatian B
AD  - School of Chemistry, Damghan University, Damghan, Iran.
FAU - Ghadamgahi, Maryam
AU  - Ghadamgahi M
AD  - School of Chemistry, Damghan University, Damghan, Iran.
FAU - Alipour, Yasin
AU  - Alipour Y
AD  - School of Chemistry, Damghan University, Damghan, Iran.
FAU - Lashgarbolouki, Taghi
AU  - Lashgarbolouki T
AD  - School of Biology, Damghan University, Damghan, Iran.
FAU - Saboury, Ali Akbar
AU  - Saboury AA
AD  - Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150319
PL  - Netherlands
TA  - Int J Biol Macromol
JT  - International journal of biological macromolecules
JID - 7909578
RN  - 0 (Nitrogen Oxides)
RN  - 0 (Schiff Bases)
RN  - 9007-49-2 (DNA)
RN  - 91080-16-9 (calf thymus DNA)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - DNA/chemistry/*metabolism
MH  - Electrochemistry
MH  - Molecular Docking Simulation
MH  - Molecular Dynamics Simulation
MH  - Nitrogen Oxides/*chemistry
MH  - Nucleic Acid Conformation
MH  - Schiff Bases/chemistry/metabolism
MH  - Temperature
OTO - NOTNLM
OT  - Calf-thymus DNA
OT  - Schiff-base
OT  - Spectroscopy
EDAT- 2015/03/23 06:00
MHDA- 2016/02/05 06:00
CRDT- 2015/03/23 06:00
PHST- 2014/11/27 00:00 [received]
PHST- 2015/03/03 00:00 [revised]
PHST- 2015/03/10 00:00 [accepted]
PHST- 2015/03/23 06:00 [entrez]
PHST- 2015/03/23 06:00 [pubmed]
PHST- 2016/02/05 06:00 [medline]
AID - S0141-8130(15)00167-1 [pii]
AID - 10.1016/j.ijbiomac.2015.03.016 [doi]
PST - ppublish
SO  - Int J Biol Macromol. 2015;77:193-202. doi: 10.1016/j.ijbiomac.2015.03.016. Epub 
      2015 Mar 19.