PMID- 25796548
OWN - NLM
STAT- MEDLINE
DCOM- 20160307
LR  - 20150609
IS  - 1878-5867 (Electronic)
IS  - 0039-128X (Linking)
VI  - 99
IP  - Pt B
DP  - 2015 Jul
TI  - "Add-on" effect of phytosterols-enriched fermented milk on lipids and markers of 
      cholesterol metabolism in statin-treated elderly patients.
PG  - 293-8
LID - S0039-128X(15)00094-X [pii]
LID - 10.1016/j.steroids.2015.03.007 [doi]
AB  - The effect of plant sterol (PS) enriched matrices on lipid profile has been 
      evaluated in statin-treated individuals, with LDL-C concentrations between 
      3.35mmol/L and 4.90mmol/L, but studies in the elderly are scarce. In this study 
      the additional effect of a low-fat PS-enriched fermented milk (PS-FM) on 
      cholesterol metabolism markers and serum lipids was evaluated in the elderly on 
      stable statin therapy with baseline LDL-C<3.35mmol/L. Thirty-five individuals 
      (88.6% women; 81+/-8years old; BMI 29.9+/-6.0kg/m(2)), living in elderly nursing care 
      facilities were placed on a daily intake of 2g PS-FM for 6weeks, in addition to 
      their statin monotherapy. A fasting blood sample was collected at baseline (t0), 
      after 2 consecutive periods of 3weeks intake (t1 and t2), and after 6weeks of 
      washout (t3), for the analysis of serum lipid profile and cholesterol synthesis 
      (lathosterol, desmosterol) and absorption (sitosterol, campesterol and 
      cholestanol) markers. PS-FM consumption led to a LDL-C reduction of 0.15mmol/L 
      (t1) and 0.27mmol/L (t2) from baseline (P<0.05). Serum campesterol and sitosterol 
      (P<0.001) increased (t0-t1; t0-t2), reflecting PS intake and contributing to the 
      inhibition of cholesterol intestinal absorption, leading to a decrease in 
      cholestanol-to-cholesterol ratio. There was a reciprocal homeostatic rise of 
      serum cholesterol precursors, desmosterol and lathosterol (P<0.001) from 
      baseline, based on the up-regulation of the opposing pathway. Statin-treated 
      elderly individuals, with baseline LDL-C<3.35mmol/L, may still have therapeutic 
      benefit from strategies that reduce cholesterol absorption, such as 2g/day PS-FM.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Andrade, Isabel
AU  - Andrade I
AD  - Instituto Politecnico de Coimbra, ESTESC-Coimbra Health School, Ciencias 
      Complementares, Rua 5 Outubro, S. Martinho do Bispo, Apartado 7006, 3046-854 
      Coimbra, Portugal; CEF - Center for Pharmaceutical Studies, Health Sciences 
      Campus, Pharmacy Faculty, University of Coimbra, Azinhaga de Santa Comba, 
      3000-548 Coimbra, Portugal. Electronic address: imandrade@estescoimbra.pt.
FAU - Santos, Lelita
AU  - Santos L
AD  - Department of Internal Medicine, Coimbra University Hospitals, Medicine Faculty, 
      University of Coimbra, 3000-075 Coimbra, Portugal.
FAU - Ramos, Fernando
AU  - Ramos F
AD  - CEF - Center for Pharmaceutical Studies, Health Sciences Campus, Pharmacy 
      Faculty, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, 
      Portugal; CNC - Center for Neuroscience and Cell Biology, Pharmacy Faculty, 
      University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal.
LA  - eng
PT  - Journal Article
DEP - 20150318
PL  - United States
TA  - Steroids
JT  - Steroids
JID - 0404536
RN  - 0 (Biomarkers)
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 0 (Phytosterols)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Aged
MH  - Animals
MH  - Biomarkers/blood/metabolism
MH  - Cholesterol/blood/*metabolism
MH  - Cholesterol, LDL/blood
MH  - Female
MH  - *Fermentation
MH  - Homeostasis/drug effects
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology
MH  - Lipid Metabolism/*drug effects
MH  - Male
MH  - Milk/*chemistry
MH  - Phytosterols/*pharmacology
OTO - NOTNLM
OT  - Cholesterol absorption markers
OT  - Cholesterol synthesis markers
OT  - Elderly
OT  - Plant sterols
OT  - Statin
EDAT- 2015/03/23 06:00
MHDA- 2016/03/08 06:00
CRDT- 2015/03/23 06:00
PHST- 2014/11/29 00:00 [received]
PHST- 2015/03/04 00:00 [revised]
PHST- 2015/03/05 00:00 [accepted]
PHST- 2015/03/23 06:00 [entrez]
PHST- 2015/03/23 06:00 [pubmed]
PHST- 2016/03/08 06:00 [medline]
AID - S0039-128X(15)00094-X [pii]
AID - 10.1016/j.steroids.2015.03.007 [doi]
PST - ppublish
SO  - Steroids. 2015 Jul;99(Pt B):293-8. doi: 10.1016/j.steroids.2015.03.007. Epub 2015 
      Mar 18.