PMID- 25796564
OWN - NLM
STAT- MEDLINE
DCOM- 20160106
LR  - 20171116
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 77
DP  - 2015 May
TI  - Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and 
      striatum from subjects with schizophrenia, bipolar disorder, and major depressive 
      disorder.
PG  - 220-7
LID - S0969-9961(15)00083-2 [pii]
LID - 10.1016/j.nbd.2015.03.011 [doi]
AB  - Brain-derived neurotrophic factor (BDNF) signaling is integral to a range of 
      neural functions, including synaptic plasticity and exhibits activity-dependent 
      regulation of expression. As altered BDNF signaling has been implicated in 
      multiple psychiatric diseases, here we report a quantitative reverse 
      transcription polymerase chain reaction (RT-PCR) analysis of mRNAs encoding TrkB, 
      total BDNF, and the four most abundant BDNF transcripts (I, IIc, IV, and VI) in 
      postmortem tissue from matched tetrads of subjects with schizophrenia, bipolar 
      disorder, or major depressive disorder (MDD) and healthy comparison subjects. In 
      all three regions examined, dorsolateral prefrontal cortex (DLPFC), associative 
      striatum and hippocampus, total BDNF mRNA levels did not differ in any disease 
      state. In DLPFC, BDNF IIc was significantly lower in schizophrenia relative to 
      healthy comparison subjects. In hippocampus, BDNF I, IIc, and VI were lower in 
      subjects with both schizophrenia and bipolar disorder relative to comparison 
      subjects. In striatum, TrkB mRNA was lower in bipolar disorder and MDD, while 
      BDNF IIc was elevated in MDD, relative to comparison subjects. These data 
      highlight potential alterations in BDNF signaling in the corticohippocampal 
      circuit in schizophrenia, and within the striatum in mood disorders. Novel 
      therapies aimed at improving BDNF-TrkB signaling may therefore have potential to 
      impact on a range of psychiatric disorders.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Reinhart, Veronica
AU  - Reinhart V
AD  - Neuroscience, Pfizer Inc., Cambridge, MA, USA.
FAU - Bove, Susan E
AU  - Bove SE
AD  - Life Technologies, New London, CT, USA.
FAU - Volfson, Dmitri
AU  - Volfson D
AD  - Research Statistics, Pfizer Inc., Cambridge, MA, USA.
FAU - Lewis, David A
AU  - Lewis DA
AD  - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
FAU - Kleiman, Robin J
AU  - Kleiman RJ
AD  - Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA.
FAU - Lanz, Thomas A
AU  - Lanz TA
AD  - Neuroscience, Pfizer Inc., Cambridge, MA, USA. Electronic address: 
      Thomas.a.lanz@pfizer.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150318
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (RNA, Messenger)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (tropomyosin-related kinase-B, human)
SB  - IM
MH  - Adult
MH  - Bipolar Disorder/*pathology
MH  - Brain/*metabolism
MH  - Brain-Derived Neurotrophic Factor/genetics/*metabolism
MH  - Corpus Striatum/metabolism
MH  - Depressive Disorder, Major/*pathology
MH  - Female
MH  - Hippocampus/metabolism
MH  - Humans
MH  - Male
MH  - Membrane Glycoproteins/*metabolism
MH  - Middle Aged
MH  - Prefrontal Cortex/metabolism
MH  - Protein-Tyrosine Kinases/*metabolism
MH  - RNA, Messenger/genetics/metabolism
MH  - Receptor, trkB
MH  - Schizophrenia/*pathology
OTO - NOTNLM
OT  - BDNF
OT  - Bipolar disorder
OT  - Postmortem
OT  - RT-PCR
OT  - Schizophrenia
OT  - TrkB
EDAT- 2015/03/23 06:00
MHDA- 2016/01/07 06:00
CRDT- 2015/03/23 06:00
PHST- 2014/10/30 00:00 [received]
PHST- 2015/01/12 00:00 [revised]
PHST- 2015/03/12 00:00 [accepted]
PHST- 2015/03/23 06:00 [entrez]
PHST- 2015/03/23 06:00 [pubmed]
PHST- 2016/01/07 06:00 [medline]
AID - S0969-9961(15)00083-2 [pii]
AID - 10.1016/j.nbd.2015.03.011 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2015 May;77:220-7. doi: 10.1016/j.nbd.2015.03.011. Epub 2015 Mar 
      18.