PMID- 25797015
OWN - NLM
STAT- MEDLINE
DCOM- 20160218
LR  - 20181202
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 22
IP  - 15
DP  - 2015 Aug
TI  - Body concentrations of persistent organic pollutants and prostate cancer: a 
      meta-analysis.
PG  - 11275-84
LID - 10.1007/s11356-015-4315-z [doi]
AB  - There have been some concerns that persistent organic pollutants (POPs) may be 
      associated with the risk of prostate cancer. Meta-analyses have not yet 
      investigated the association between human-biomonitoring data for POPs and 
      prostate cancer risk. The purpose of this study was to assess the association 
      between body concentration of individual compounds or mixtures of POPs and 
      prostate cancer risk in the general population by performing a meta-analysis. A 
      literature search was performed using PubMed, EMBASE, and KoreaMed from the 
      period 1950 through 2014. The odds ratio (OR) and its 95% confidence interval 
      (CI) of prostate cancer associated with POPs were estimated using fixed-effects 
      model or random-effects model where appropriate. Dose-response relationships were 
      assessed by using the generalized least-squares method for trend estimation. A 
      total of eight (six case-control, one cross-sectional, one nested case-control) 
      studies including 1158 prostate cancer cases among 6932 subjects were selected 
      for the meta-analysis. Total POPs of interest showed positive associations with 
      statistical significance on prostate cancer (OR 1.31, 95% CI 1.13, 1.57). In 
      dose-response meta-analysis, 1 mug/g lipid of PCBs was found to be associated with 
      a 49% increased risk of prostate cancer (OR 1.49, 95% CI 1.07, 2.06). One 
      nanogram per gram (1000 mug/g) lipid of trans-nonachlor was found to be associated 
      with approximately 2% increased risk of prostate cancer (OR = 1.02/1 ng/g lipid 
      of trans-nonachlor, 95% CI 1.00, 1.03). The available evidence suggests that body 
      concentrations of POPs are positively associated with prostate cancer risk, which 
      implies valuable evidence for prostate cancer prevention.
FAU - Lim, Jung-eun
AU  - Lim JE
AD  - Institute for Health Promotion & Department of Epidemiology and Health Promotion, 
      Graduate School of Public Health, Yonsei University, Seoul, Republic of Korea.
FAU - Park, Su Hyun
AU  - Park SH
FAU - Jee, Sun Ha
AU  - Jee SH
FAU - Park, Hyesook
AU  - Park H
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
DEP - 20150324
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Environmental Pollutants)
RN  - 0 (Organic Chemicals)
SB  - IM
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*metabolism/toxicity
MH  - Humans
MH  - Male
MH  - Models, Statistical
MH  - Organic Chemicals/*metabolism/toxicity
MH  - Prostatic Neoplasms/chemically induced/epidemiology/*metabolism
MH  - Risk
EDAT- 2015/03/24 06:00
MHDA- 2016/02/19 06:00
CRDT- 2015/03/24 06:00
PHST- 2014/12/15 00:00 [received]
PHST- 2015/03/02 00:00 [accepted]
PHST- 2015/03/24 06:00 [entrez]
PHST- 2015/03/24 06:00 [pubmed]
PHST- 2016/02/19 06:00 [medline]
AID - 10.1007/s11356-015-4315-z [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2015 Aug;22(15):11275-84. doi: 
      10.1007/s11356-015-4315-z. Epub 2015 Mar 24.