PMID- 25797068
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20150429
IS  - 1502-7686 (Electronic)
IS  - 0036-5513 (Linking)
VI  - 75
IP  - 4
DP  - 2015 Jul
TI  - Increased plasma monocyte chemoattractant protein-1 levels in patients with 
      isolated low high-density lipoprotein cholesterol.
PG  - 327-32
LID - 10.3109/00365513.2014.1003595 [doi]
AB  - BACKGROUND: High-density lipoprotein cholesterol (HDL-C) inhibits inflammation 
      associated with the development of atherosclerotic plaques. Monocyte 
      chemoattractant protein-1 (MCP-1) contributes to the pathogenesis of 
      atherosclerosis. The aim of this study was to evaluate the relationship between 
      plasma MCP-1 levels and low HDL-C levels in patients without cardiovascular 
      disease (CVD). METHODS: This study included 55 patients with low HDL-C (</= 35 
      mg/dL) and 33 age- and sex-matched control subjects with normal HDL-C (> 35 
      mg/dL). In addition to MCP-1 levels, laboratory parameters associated with 
      inflammation such as neutrophil-lymphocyte ratio (NLR), uric acid and high 
      sensitivity C-reactive protein (hs-CRP) were also evaluated. RESULTS: HDL-C 
      levels was significantly lower in study group compared to that of the control 
      group (p < 0.001). MCP-1 were prominently higher in the low HDL-C group compared 
      with those of the control group (p < 0.01). NLR, uric acid and hs-CRP levels were 
      also higher in patients with low HDL-C than controls. CONCLUSION: These findings 
      suggest that elevated plasma MCP-1 levels and inflammation status might be 
      associated with the increased cardiovascular risk in patients with low HDL-C.
FAU - Karabacak, Mustafa
AU  - Karabacak M
AD  - Department of Cardiology, Isparta State Hospital , Isparta.
FAU - Kahraman, Fatih
AU  - Kahraman F
FAU - Sert, Mehmet
AU  - Sert M
FAU - Celik, Erdal
AU  - Celik E
FAU - Adali, Mehmet Koray
AU  - Adali MK
FAU - Varol, Ercan
AU  - Varol E
LA  - eng
PT  - Journal Article
DEP - 20150323
PL  - England
TA  - Scand J Clin Lab Invest
JT  - Scandinavian journal of clinical and laboratory investigation
JID - 0404375
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cholesterol, HDL)
RN  - 268B43MJ25 (Uric Acid)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - C-Reactive Protein/metabolism
MH  - Chemokine CCL2/*blood
MH  - Cholesterol, HDL/*blood
MH  - Female
MH  - Humans
MH  - Leukocyte Count
MH  - Linear Models
MH  - Male
MH  - Middle Aged
MH  - Uric Acid/blood
OTO - NOTNLM
OT  - High-density lipoprotein cholesterol
OT  - inflammation
OT  - monocyte chemoattractant protein-1
OT  - uric acid
EDAT- 2015/03/24 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/03/24 06:00
PHST- 2015/03/24 06:00 [entrez]
PHST- 2015/03/24 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - 10.3109/00365513.2014.1003595 [doi]
PST - ppublish
SO  - Scand J Clin Lab Invest. 2015 Jul;75(4):327-32. doi: 
      10.3109/00365513.2014.1003595. Epub 2015 Mar 23.