PMID- 25797205
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20150606
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 76
IP  - 6
DP  - 2015 Jun
TI  - Role of scavenger receptors in dendritic cell function.
PG  - 442-6
LID - S0198-8859(15)00104-4 [pii]
LID - 10.1016/j.humimm.2015.03.012 [doi]
AB  - Dendritic cells (DCs), the most potent of the antigen-presenting cells, are 
      crucial in initiating and shaping innate and adaptive immune responses. DCs 
      discriminate unmodified self antigens from non-self and altered/modified self 
      antigens via a large family of receptors called pattern-recognition receptors, 
      which include Toll-like receptors and scavenger receptors (SRs). Recent findings 
      underscore the critical role of SRs on DCs in pathogen clearance, 
      atherosclerosis, apoptotic cell recognition, diesel exhaust particle recognition, 
      etc. These new findings present SRs as an unexplored therapeutic target that 
      warrants further basic and applied research, and have implications for vaccine 
      development. This review highlights recent insights into the emerging role of 
      these receptors in DC-mediated immune responses.
CI  - Copyright (c) 2015 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Wang, Dan
AU  - Wang D
AD  - Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, 
      Jinan 250021, Shandong, PR China.
FAU - Sun, Bo
AU  - Sun B
AD  - Shandong Medical Imaging Research Institute, Shandong University, 324 Jing Wu 
      Road, Jinan 250021, Shandong, PR China. Electronic address: sunboy4554@163.com.
FAU - Feng, Mei
AU  - Feng M
AD  - Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, 
      Jinan 250021, Shandong, PR China.
FAU - Feng, Hong
AU  - Feng H
AD  - Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, 
      Jinan 250021, Shandong, PR China.
FAU - Gong, Wuxian
AU  - Gong W
AD  - Shandong Medical Imaging Research Institute, Shandong University, 324 Jing Wu 
      Road, Jinan 250021, Shandong, PR China.
FAU - Liu, Qiang
AU  - Liu Q
AD  - Shandong Medical Imaging Research Institute, Shandong University, 324 Jing Wu 
      Road, Jinan 250021, Shandong, PR China.
FAU - Ge, Shujian
AU  - Ge S
AD  - Shandong Provincial Hospital affiliated to Shandong University, 324 Jing Wu Road, 
      Jinan 250021, Shandong, PR China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20150320
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (Antigens, Bacterial)
RN  - 0 (Antigens, Viral)
RN  - 0 (Particulate Matter)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Toll-Like Receptors)
SB  - IM
MH  - Adaptive Immunity
MH  - *Antigen Presentation
MH  - Antigens, Bacterial/chemistry/*immunology
MH  - Antigens, Viral/chemistry/*immunology
MH  - Apoptosis
MH  - Cell Communication
MH  - Dendritic Cells/cytology/immunology/*metabolism
MH  - Gene Expression Regulation
MH  - Humans
MH  - Immunity, Innate
MH  - Particulate Matter/chemistry/immunology
MH  - Receptors, Scavenger/*genetics/immunology
MH  - Signal Transduction
MH  - Toll-Like Receptors/*genetics/immunology
OTO - NOTNLM
OT  - Antigen-presenting cells
OT  - Dendritic cell
OT  - Scavenger receptors
EDAT- 2015/03/24 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/03/24 06:00
PHST- 2014/08/03 00:00 [received]
PHST- 2015/02/05 00:00 [revised]
PHST- 2015/03/11 00:00 [accepted]
PHST- 2015/03/24 06:00 [entrez]
PHST- 2015/03/24 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - S0198-8859(15)00104-4 [pii]
AID - 10.1016/j.humimm.2015.03.012 [doi]
PST - ppublish
SO  - Hum Immunol. 2015 Jun;76(6):442-6. doi: 10.1016/j.humimm.2015.03.012. Epub 2015 
      Mar 20.