PMID- 2579817
OWN - NLM
STAT- MEDLINE
DCOM- 19850430
LR  - 20180214
IS  - 0014-3022 (Print)
IS  - 0014-3022 (Linking)
VI  - 24
IP  - 2
DP  - 1985
TI  - Local immunoglobulin synthesis and blood-brain barrier assessment in subacute 
      sclerosing panencephalitis.
PG  - 128-33
AB  - The immunoglobulin synthesis within the central nervous system and the 
      blood-brain barrier (BBB) function were evaluated in 6 patients with subacute 
      sclerosing panencephalitis (SSPE) using the IgG index and a graphic method based 
      on serum/CSF albumin, alpha 2-macroglobulin, and IgG quotients. A strong local 
      production of IgG was documented by both methods in all 6 cases of SSPE. 
      Concerning the graphic analysis, the decrease in the serum/CSF alpha 
      2-macroglobulin ratio disclosed BBB dysfunction in 2 cases of SSPE, suggesting, 
      in the absence of the serum/CSF albumin quotient abnormalities, that a 
      homeostatic mechanism for CSF proteins can cause changes in the CSF protein 
      profile.
FAU - Silva, C A
AU  - Silva CA
FAU - Rio, M E
AU  - Rio ME
FAU - Cruz, C
AU  - Cruz C
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Eur Neurol
JT  - European neurology
JID - 0150760
RN  - 0 (Immunoglobulin A)
RN  - 0 (Immunoglobulin G)
RN  - 0 (Immunoglobulins)
RN  - 0 (Serum Albumin)
RN  - 0 (alpha-Macroglobulins)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Blood-Brain Barrier
MH  - Child
MH  - Humans
MH  - Immunoglobulin A/cerebrospinal fluid
MH  - Immunoglobulin G/cerebrospinal fluid
MH  - Immunoglobulins/*cerebrospinal fluid
MH  - Male
MH  - Serum Albumin/cerebrospinal fluid
MH  - Subacute Sclerosing Panencephalitis/*immunology
MH  - alpha-Macroglobulins/cerebrospinal fluid
EDAT- 1985/01/01 00:00
MHDA- 1985/01/01 00:01
CRDT- 1985/01/01 00:00
PHST- 1985/01/01 00:00 [pubmed]
PHST- 1985/01/01 00:01 [medline]
PHST- 1985/01/01 00:00 [entrez]
AID - 10.1159/000115773 [doi]
PST - ppublish
SO  - Eur Neurol. 1985;24(2):128-33. doi: 10.1159/000115773.