PMID- 25799087
OWN - NLM
STAT- MEDLINE
DCOM- 20160223
LR  - 20180816
IS  - 1873-7714 (Electronic)
IS  - 0163-8343 (Linking)
VI  - 37
IP  - 3
DP  - 2015 May-Jun
TI  - Serum brain-derived neurotrophic factor differences between the luteal and 
      follicular phases in premenstrual dysphoric disorder.
PG  - 266-72
LID - S0163-8343(15)00042-0 [pii]
LID - 10.1016/j.genhosppsych.2015.03.001 [doi]
AB  - OBJECTIVE: We hypothesized that comparison of the serum brain-derived 
      neurotrophic factor (BDNF) levels between women with premenstrual dysphoric 
      disorder (PMDD) and women without PMDD in the luteal and follicular phases of 
      their menstrual cycles would reflect the altered neuromodulator responses that 
      compensate the underlying pathogenesis in PMDD. METHOD: Twenty-nine participants 
      without PMDD and 20 with PMDD were enrolled in the study. The serum BDNF, 
      estrogen and progesterone levels were assessed at the follicular and luteal 
      phases in their two consecutive menstrual cycles. RESULTS: Participants with PMDD 
      had significantly higher luteal serum BDNF levels than the control subjects. The 
      serum BDNF levels were significantly higher in the luteal phase than in the 
      follicular phase in women with PMDD. The difference in the serum BDNF levels 
      between the luteal and follicular phases were significantly higher in the PMDD 
      patients than in the control. CONCLUSIONS: The higher serum BDNF levels in the 
      luteal phase in the PMDD patients may reflect compensatory process that results 
      in subsequent improvement of the PMDD-associated depressive symptoms in the 
      follicular phase. The higher difference in the serum BDNF levels between the 
      phases in PMDD patients may reflect an altered neuromodulator response.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Oral, Elif
AU  - Oral E
AD  - Department of Psychiatry, Medical Faculty, Ataturk University, Erzurum, Turkey. 
      Electronic address: oralelif@yahoo.com.
FAU - Kirkan, Tulay Sati
AU  - Kirkan TS
AD  - Department of Psychiatry, Erzurum Regional Training and Research Hospital, 
      Erzurum, Turkey.
FAU - Yildirim, Abdulkadir
AU  - Yildirim A
AD  - Department of Biochemistry, Medical Faculty, Ataturk University, Erzurum, Turkey.
FAU - Kotan, Zerrin
AU  - Kotan Z
AD  - Department of Biochemistry, Pharmacy Faculty, Ataturk University, Erzurum, 
      Turkey.
FAU - Cansever, Zeliha
AU  - Cansever Z
AD  - Department of Medical Education, Medical Faculty, Ataturk University, Erzurum, 
      Turkey.
FAU - Ozcan, Halil
AU  - Ozcan H
AD  - Department of Psychiatry, Medical Faculty, Ataturk University, Erzurum, Turkey.
FAU - Aliyev, Elvin
AU  - Aliyev E
AD  - Department of Biochemistry, Medical Faculty, Ataturk University, Erzurum, Turkey.
FAU - Gulec, Mustafa
AU  - Gulec M
AD  - Department of Psychiatry, Medical Faculty, Katip Celebi University, Izmir, 
      Turkey.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150311
PL  - United States
TA  - Gen Hosp Psychiatry
JT  - General hospital psychiatry
JID - 7905527
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adult
MH  - Brain-Derived Neurotrophic Factor/*blood
MH  - Female
MH  - Follicular Phase/*blood
MH  - Humans
MH  - Luteal Phase/*blood
MH  - Premenstrual Dysphoric Disorder/*blood
MH  - Young Adult
OTO - NOTNLM
OT  - Brain-derived neurotrophic factor
OT  - Follicular
OT  - Luteal
OT  - Premenstrual dysphoric disorder
EDAT- 2015/03/24 06:00
MHDA- 2016/02/26 06:00
CRDT- 2015/03/24 06:00
PHST- 2013/01/25 00:00 [received]
PHST- 2015/01/30 00:00 [revised]
PHST- 2015/03/05 00:00 [accepted]
PHST- 2015/03/24 06:00 [entrez]
PHST- 2015/03/24 06:00 [pubmed]
PHST- 2016/02/26 06:00 [medline]
AID - S0163-8343(15)00042-0 [pii]
AID - 10.1016/j.genhosppsych.2015.03.001 [doi]
PST - ppublish
SO  - Gen Hosp Psychiatry. 2015 May-Jun;37(3):266-72. doi: 
      10.1016/j.genhosppsych.2015.03.001. Epub 2015 Mar 11.