PMID- 25799553
OWN - NLM
STAT- MEDLINE
DCOM- 20160209
LR  - 20181113
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 3
DP  - 2015
TI  - A comparison of radiologic tumor volume and pathologic tumor volume in renal cell 
      carcinoma (RCC).
PG  - e0122019
LID - 10.1371/journal.pone.0122019 [doi]
LID - e0122019
AB  - OBJECTIVE: To investigate the difference between preoperative radiologic tumor 
      volume (RTV) and postoperative pathologic tumor volume (PTV) in patients who 
      received nephrectomy for renal cell carcinoma (RCC). MATERIALS AND METHODS: We 
      reviewed 482 patients who underwent preoperative computed tomography (CT) within 
      4 weeks before radical or partial nephrectomy for renal cell carcinoma. RTV 
      measured by a three dimensional rendering program was compared with PTV (pi/6 x 
      height x length x width) measured in surgical specimen according to pathologic 
      tumor size and histologic subtype. Correlation of the inter-quartile range (IQR) 
      of the RTV and Fuhrman nuclear grade was also investigated. RESULTS: There was a 
      significant positive linear correlation between RTV and PTV (p < 0.001, r = 
      0.911), and the mean RTV and mean PTV were not significantly different (79.0 vs 
      76.9 cm3, p = 0.393). For pathologic tumor size (PTS) < 4 cm, the mean RTV was 
      larger than the mean PTV (10.9 vs 7.1 cm3, p < 0.001). For a PTS of 4-7 cm, the 
      mean RTV was larger than the mean PTV (56.0 vs 44.7 cm3, p < 0.001). However, for 
      a PTS >/= 7 cm, there was no statistical difference between RTV and PTV (p > 0.05). 
      Among patients with clear cell RCC, the mean RTV was significantly larger than 
      the mean PTV (p = 0.042), not for non-clear cell group (p = 0.055). As the 
      quartile of the RTV increased, the Fuhrman grade also increased (p < 0.001). 
      CONCLUSIONS: RTV was correlated with PTV and pathologic grade. RTV was larger 
      than the PTV for a tumor size 7 cm or less or in clear cell RCC. RTV may be 
      useful to measure tumor burden preoperatively.
FAU - Choi, See Min
AU  - Choi SM
AD  - Department of Urology, Gyeongsang National University Hospital, Gyeongsang 
      National University School of medicine, Jinju, Korea.
FAU - Choi, Don Kyoung
AU  - Choi DK
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Kim, Tae Heon
AU  - Kim TH
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Jeong, Byong Chang
AU  - Jeong BC
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Seo, Seong Il
AU  - Seo SI
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Jeon, Seong Soo
AU  - Jeon SS
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Lee, Hyun Moo
AU  - Lee HM
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Choi, Han-Yong
AU  - Choi HY
AD  - Department of Urology, Samsung Medical Center, Sungkyunkwan University School of 
      Medicine, Seoul, Korea.
FAU - Jeon, Hwang Gyun
AU  - Jeon HG
AD  - Department of Urology, Samsung Medical Center, Samsung Biomedical Research 
      Institute, Sungkyunkwan University School of Medicine, Seoul, Korea.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150323
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Renal Cell/*diagnostic imaging/*pathology/surgery
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - Kidney Neoplasms/*diagnostic imaging/*pathology/surgery
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Grading
MH  - Neoplasm Staging
MH  - Nephrectomy
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Tomography, X-Ray Computed
MH  - Tumor Burden
MH  - Young Adult
PMC - PMC4370411
COIS- Competing Interests: The authors have declared that no competing interests exist.
EDAT- 2015/03/24 06:00
MHDA- 2016/02/10 06:00
PMCR- 2015/03/23
CRDT- 2015/03/24 06:00
PHST- 2014/11/30 00:00 [received]
PHST- 2015/02/09 00:00 [accepted]
PHST- 2015/03/24 06:00 [entrez]
PHST- 2015/03/24 06:00 [pubmed]
PHST- 2016/02/10 06:00 [medline]
PHST- 2015/03/23 00:00 [pmc-release]
AID - PONE-D-14-53042 [pii]
AID - 10.1371/journal.pone.0122019 [doi]
PST - epublish
SO  - PLoS One. 2015 Mar 23;10(3):e0122019. doi: 10.1371/journal.pone.0122019. 
      eCollection 2015.